Cargando…
Classification of atopic dermatitis phenotypes according to allergic sensitization by cluster analysis
A cluster study to classify atopic dermatitis (AD) phenotypes into subgroups is required to better understand and manage the disease owing to the heterogeneity of its clinical features. This study aimed to identify the phenotypic subgroups of childhood AD according to allergic sensitization. In 258...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
World Allergy Organization
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357948/ https://www.ncbi.nlm.nih.gov/pubmed/35983566 http://dx.doi.org/10.1016/j.waojou.2022.100671 |
_version_ | 1784763822410563584 |
---|---|
author | Yum, Hye Yung Lee, Ji Su Bae, Jung Min Lee, Sooyoung Kim, Yun Hee Sung, Myongsoon Yang, Song-I Lee, Jeongmin Lee, Mi-Hee Lee, Dong Hun |
author_facet | Yum, Hye Yung Lee, Ji Su Bae, Jung Min Lee, Sooyoung Kim, Yun Hee Sung, Myongsoon Yang, Song-I Lee, Jeongmin Lee, Mi-Hee Lee, Dong Hun |
author_sort | Yum, Hye Yung |
collection | PubMed |
description | A cluster study to classify atopic dermatitis (AD) phenotypes into subgroups is required to better understand and manage the disease owing to the heterogeneity of its clinical features. This study aimed to identify the phenotypic subgroups of childhood AD according to allergic sensitization. In 258 children with AD, hierarchical cluster analysis based on specific immunoglobulin (Ig) E sensitization revealed four distinct clusters. Cluster A (n = 71) revealed no IgE sensitization, whereas cluster B (n = 28) showed sensitization to egg white only. Cluster B was highly associated with early-onset AD (<3 months) and a family history of atopic diseases. Cluster C (n = 68) and D (n = 91), sensitized to multiple foods and inhalants, respectively, showed a higher prevalence of skin infection within the last 1 year than others. Cluster D was related to late-onset AD (>12 months) and had more atopic comorbidities. In addition, cluster D showed the most severely impaired health-related quality of life and more frequent use of immunosuppressants. Therefore, childhood AD can be classified into 4 clusters based on the allergic sensitization status, and clinical phenotypes and treatment strategy may be different according to clusters. |
format | Online Article Text |
id | pubmed-9357948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | World Allergy Organization |
record_format | MEDLINE/PubMed |
spelling | pubmed-93579482022-08-17 Classification of atopic dermatitis phenotypes according to allergic sensitization by cluster analysis Yum, Hye Yung Lee, Ji Su Bae, Jung Min Lee, Sooyoung Kim, Yun Hee Sung, Myongsoon Yang, Song-I Lee, Jeongmin Lee, Mi-Hee Lee, Dong Hun World Allergy Organ J Correspondence A cluster study to classify atopic dermatitis (AD) phenotypes into subgroups is required to better understand and manage the disease owing to the heterogeneity of its clinical features. This study aimed to identify the phenotypic subgroups of childhood AD according to allergic sensitization. In 258 children with AD, hierarchical cluster analysis based on specific immunoglobulin (Ig) E sensitization revealed four distinct clusters. Cluster A (n = 71) revealed no IgE sensitization, whereas cluster B (n = 28) showed sensitization to egg white only. Cluster B was highly associated with early-onset AD (<3 months) and a family history of atopic diseases. Cluster C (n = 68) and D (n = 91), sensitized to multiple foods and inhalants, respectively, showed a higher prevalence of skin infection within the last 1 year than others. Cluster D was related to late-onset AD (>12 months) and had more atopic comorbidities. In addition, cluster D showed the most severely impaired health-related quality of life and more frequent use of immunosuppressants. Therefore, childhood AD can be classified into 4 clusters based on the allergic sensitization status, and clinical phenotypes and treatment strategy may be different according to clusters. World Allergy Organization 2022-08-03 /pmc/articles/PMC9357948/ /pubmed/35983566 http://dx.doi.org/10.1016/j.waojou.2022.100671 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Correspondence Yum, Hye Yung Lee, Ji Su Bae, Jung Min Lee, Sooyoung Kim, Yun Hee Sung, Myongsoon Yang, Song-I Lee, Jeongmin Lee, Mi-Hee Lee, Dong Hun Classification of atopic dermatitis phenotypes according to allergic sensitization by cluster analysis |
title | Classification of atopic dermatitis phenotypes according to allergic sensitization by cluster analysis |
title_full | Classification of atopic dermatitis phenotypes according to allergic sensitization by cluster analysis |
title_fullStr | Classification of atopic dermatitis phenotypes according to allergic sensitization by cluster analysis |
title_full_unstemmed | Classification of atopic dermatitis phenotypes according to allergic sensitization by cluster analysis |
title_short | Classification of atopic dermatitis phenotypes according to allergic sensitization by cluster analysis |
title_sort | classification of atopic dermatitis phenotypes according to allergic sensitization by cluster analysis |
topic | Correspondence |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357948/ https://www.ncbi.nlm.nih.gov/pubmed/35983566 http://dx.doi.org/10.1016/j.waojou.2022.100671 |
work_keys_str_mv | AT yumhyeyung classificationofatopicdermatitisphenotypesaccordingtoallergicsensitizationbyclusteranalysis AT leejisu classificationofatopicdermatitisphenotypesaccordingtoallergicsensitizationbyclusteranalysis AT baejungmin classificationofatopicdermatitisphenotypesaccordingtoallergicsensitizationbyclusteranalysis AT leesooyoung classificationofatopicdermatitisphenotypesaccordingtoallergicsensitizationbyclusteranalysis AT kimyunhee classificationofatopicdermatitisphenotypesaccordingtoallergicsensitizationbyclusteranalysis AT sungmyongsoon classificationofatopicdermatitisphenotypesaccordingtoallergicsensitizationbyclusteranalysis AT yangsongi classificationofatopicdermatitisphenotypesaccordingtoallergicsensitizationbyclusteranalysis AT leejeongmin classificationofatopicdermatitisphenotypesaccordingtoallergicsensitizationbyclusteranalysis AT leemihee classificationofatopicdermatitisphenotypesaccordingtoallergicsensitizationbyclusteranalysis AT leedonghun classificationofatopicdermatitisphenotypesaccordingtoallergicsensitizationbyclusteranalysis |