Cargando…

Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population: ABIS study

Although gut microbiome dysbiosis has been illustrated in celiac disease (CD), there are disagreements about what constitutes these microbial signatures and the timeline by which they precede diagnosis is largely unknown. The study of high-genetic-risk patients or those already with CD limits our kn...

Descripción completa

Detalles Bibliográficos
Autores principales: Milletich, Patricia L., Ahrens, Angelica P., Russell, Jordan T., Petrone, Joseph R., Berryman, Meghan A., Agardh, Daniel, Ludvigsson, Jonas F., Triplett, Eric W., Ludvigsson, Johnny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357981/
https://www.ncbi.nlm.nih.gov/pubmed/35959362
http://dx.doi.org/10.3389/fcimb.2022.920735
_version_ 1784763830745694208
author Milletich, Patricia L.
Ahrens, Angelica P.
Russell, Jordan T.
Petrone, Joseph R.
Berryman, Meghan A.
Agardh, Daniel
Ludvigsson, Jonas F.
Triplett, Eric W.
Ludvigsson, Johnny
author_facet Milletich, Patricia L.
Ahrens, Angelica P.
Russell, Jordan T.
Petrone, Joseph R.
Berryman, Meghan A.
Agardh, Daniel
Ludvigsson, Jonas F.
Triplett, Eric W.
Ludvigsson, Johnny
author_sort Milletich, Patricia L.
collection PubMed
description Although gut microbiome dysbiosis has been illustrated in celiac disease (CD), there are disagreements about what constitutes these microbial signatures and the timeline by which they precede diagnosis is largely unknown. The study of high-genetic-risk patients or those already with CD limits our knowledge of dysbiosis that may occur early in life in a generalized population. To explore early gut microbial imbalances correlated with future celiac disease (fCD), we analyzed the stool of 1478 infants aged one year, 26 of whom later acquired CD, with a mean age of diagnosis of 10.96 ± 5.6 years. With a novel iterative control-matching algorithm using the prospective general population cohort, All Babies In Southeast Sweden, we found nine core microbes with prevalence differences and seven differentially abundant bacteria between fCD infants and controls. The differences were validated using 100 separate, iterative permutations of matched controls, which suggests the bacterial signatures are significant in fCD even when accounting for the inherent variability in a general population. This work is the first to our knowledge to demonstrate that gut microbial differences in prevalence and abundance exist in infants aged one year up to 19 years before a diagnosis of CD in a general population.
format Online
Article
Text
id pubmed-9357981
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93579812022-08-10 Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population: ABIS study Milletich, Patricia L. Ahrens, Angelica P. Russell, Jordan T. Petrone, Joseph R. Berryman, Meghan A. Agardh, Daniel Ludvigsson, Jonas F. Triplett, Eric W. Ludvigsson, Johnny Front Cell Infect Microbiol Cellular and Infection Microbiology Although gut microbiome dysbiosis has been illustrated in celiac disease (CD), there are disagreements about what constitutes these microbial signatures and the timeline by which they precede diagnosis is largely unknown. The study of high-genetic-risk patients or those already with CD limits our knowledge of dysbiosis that may occur early in life in a generalized population. To explore early gut microbial imbalances correlated with future celiac disease (fCD), we analyzed the stool of 1478 infants aged one year, 26 of whom later acquired CD, with a mean age of diagnosis of 10.96 ± 5.6 years. With a novel iterative control-matching algorithm using the prospective general population cohort, All Babies In Southeast Sweden, we found nine core microbes with prevalence differences and seven differentially abundant bacteria between fCD infants and controls. The differences were validated using 100 separate, iterative permutations of matched controls, which suggests the bacterial signatures are significant in fCD even when accounting for the inherent variability in a general population. This work is the first to our knowledge to demonstrate that gut microbial differences in prevalence and abundance exist in infants aged one year up to 19 years before a diagnosis of CD in a general population. Frontiers Media S.A. 2022-07-25 /pmc/articles/PMC9357981/ /pubmed/35959362 http://dx.doi.org/10.3389/fcimb.2022.920735 Text en Copyright © 2022 Milletich, Ahrens, Russell, Petrone, Berryman, Agardh, Ludvigsson, Triplett and Ludvigsson https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Milletich, Patricia L.
Ahrens, Angelica P.
Russell, Jordan T.
Petrone, Joseph R.
Berryman, Meghan A.
Agardh, Daniel
Ludvigsson, Jonas F.
Triplett, Eric W.
Ludvigsson, Johnny
Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population: ABIS study
title Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population: ABIS study
title_full Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population: ABIS study
title_fullStr Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population: ABIS study
title_full_unstemmed Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population: ABIS study
title_short Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population: ABIS study
title_sort gut microbiome markers in subgroups of hla class ii genotyped infants signal future celiac disease in the general population: abis study
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357981/
https://www.ncbi.nlm.nih.gov/pubmed/35959362
http://dx.doi.org/10.3389/fcimb.2022.920735
work_keys_str_mv AT milletichpatricial gutmicrobiomemarkersinsubgroupsofhlaclassiigenotypedinfantssignalfutureceliacdiseaseinthegeneralpopulationabisstudy
AT ahrensangelicap gutmicrobiomemarkersinsubgroupsofhlaclassiigenotypedinfantssignalfutureceliacdiseaseinthegeneralpopulationabisstudy
AT russelljordant gutmicrobiomemarkersinsubgroupsofhlaclassiigenotypedinfantssignalfutureceliacdiseaseinthegeneralpopulationabisstudy
AT petronejosephr gutmicrobiomemarkersinsubgroupsofhlaclassiigenotypedinfantssignalfutureceliacdiseaseinthegeneralpopulationabisstudy
AT berrymanmeghana gutmicrobiomemarkersinsubgroupsofhlaclassiigenotypedinfantssignalfutureceliacdiseaseinthegeneralpopulationabisstudy
AT agardhdaniel gutmicrobiomemarkersinsubgroupsofhlaclassiigenotypedinfantssignalfutureceliacdiseaseinthegeneralpopulationabisstudy
AT ludvigssonjonasf gutmicrobiomemarkersinsubgroupsofhlaclassiigenotypedinfantssignalfutureceliacdiseaseinthegeneralpopulationabisstudy
AT triplettericw gutmicrobiomemarkersinsubgroupsofhlaclassiigenotypedinfantssignalfutureceliacdiseaseinthegeneralpopulationabisstudy
AT ludvigssonjohnny gutmicrobiomemarkersinsubgroupsofhlaclassiigenotypedinfantssignalfutureceliacdiseaseinthegeneralpopulationabisstudy