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Candida species and selected behavioral factors co-associated with severe early childhood caries: Case-control study
Severe Early Childhood Caries (sECC) is a multifactorial disease associated with the occurrence of specific oral microorganisms and other environmental, behavioral, and genetic factors. This study aimed to construct a multivariable model including the occurrence of Candida spp. and selected behavior...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357982/ https://www.ncbi.nlm.nih.gov/pubmed/35959372 http://dx.doi.org/10.3389/fcimb.2022.943480 |
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author | Cvanova, Michaela Ruzicka, Filip Kukletova, Martina Lipovy, Bretislav Gachova, Daniela Izakovicova Holla, Lydie Danek, Zdenek Hola, Veronika Bartosova, Michaela Jarkovsky, Jiri Dusek, Ladislav Borilova Linhartova, Petra |
author_facet | Cvanova, Michaela Ruzicka, Filip Kukletova, Martina Lipovy, Bretislav Gachova, Daniela Izakovicova Holla, Lydie Danek, Zdenek Hola, Veronika Bartosova, Michaela Jarkovsky, Jiri Dusek, Ladislav Borilova Linhartova, Petra |
author_sort | Cvanova, Michaela |
collection | PubMed |
description | Severe Early Childhood Caries (sECC) is a multifactorial disease associated with the occurrence of specific oral microorganisms and other environmental, behavioral, and genetic factors. This study aimed to construct a multivariable model including the occurrence of Candida spp. and selected behavioral factors (length of breastfeeding, serving sweet beverages and beginning of brushing child’s teeth) to determine their relationships to the occurrence of sECC. In this case-control study 164 children with sECC and 147 children without dental caries were included. MALDI-TOF MS and multiplex qPCR were used to identify Candida spp. and selected bacteria in dental plaque samples, respectively. A questionnaire on oral hygiene, diet, and children’s health was filled in by the parents. The constructed multivariable logistic regression model showed an independent influence of the microbial and behavioral factors in sECC etiopathogenesis. The occurrence of C. albicans and C. dubliniensis was associated with higher odds of sECC development (odds ratio, OR: 9.62 and 16.93, respectively), together with breastfeeding of 6 months or less (OR: 2.71), exposure to sweet beverages (OR: 3.77), and starting to brush child’s teeth after the 12(th) month of age (OR: 4.10), all statistically significant (p < 0.01). Considering the high occurrence of C. albicans and C. dubliniensis in dental plaque in children with sECC, we propose them as “keystone pathogens” and risk factors for sECC. The models showed that presence of specific species of Candida in dental plaque may be a better descriptor of sECC than the mentioned behavioral factors. |
format | Online Article Text |
id | pubmed-9357982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93579822022-08-10 Candida species and selected behavioral factors co-associated with severe early childhood caries: Case-control study Cvanova, Michaela Ruzicka, Filip Kukletova, Martina Lipovy, Bretislav Gachova, Daniela Izakovicova Holla, Lydie Danek, Zdenek Hola, Veronika Bartosova, Michaela Jarkovsky, Jiri Dusek, Ladislav Borilova Linhartova, Petra Front Cell Infect Microbiol Cellular and Infection Microbiology Severe Early Childhood Caries (sECC) is a multifactorial disease associated with the occurrence of specific oral microorganisms and other environmental, behavioral, and genetic factors. This study aimed to construct a multivariable model including the occurrence of Candida spp. and selected behavioral factors (length of breastfeeding, serving sweet beverages and beginning of brushing child’s teeth) to determine their relationships to the occurrence of sECC. In this case-control study 164 children with sECC and 147 children without dental caries were included. MALDI-TOF MS and multiplex qPCR were used to identify Candida spp. and selected bacteria in dental plaque samples, respectively. A questionnaire on oral hygiene, diet, and children’s health was filled in by the parents. The constructed multivariable logistic regression model showed an independent influence of the microbial and behavioral factors in sECC etiopathogenesis. The occurrence of C. albicans and C. dubliniensis was associated with higher odds of sECC development (odds ratio, OR: 9.62 and 16.93, respectively), together with breastfeeding of 6 months or less (OR: 2.71), exposure to sweet beverages (OR: 3.77), and starting to brush child’s teeth after the 12(th) month of age (OR: 4.10), all statistically significant (p < 0.01). Considering the high occurrence of C. albicans and C. dubliniensis in dental plaque in children with sECC, we propose them as “keystone pathogens” and risk factors for sECC. The models showed that presence of specific species of Candida in dental plaque may be a better descriptor of sECC than the mentioned behavioral factors. Frontiers Media S.A. 2022-07-25 /pmc/articles/PMC9357982/ /pubmed/35959372 http://dx.doi.org/10.3389/fcimb.2022.943480 Text en Copyright © 2022 Cvanova, Ruzicka, Kukletova, Lipovy, Gachova, Izakovicova Holla, Danek, Hola, Bartosova, Jarkovsky, Dusek and Borilova Linhartova https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Cvanova, Michaela Ruzicka, Filip Kukletova, Martina Lipovy, Bretislav Gachova, Daniela Izakovicova Holla, Lydie Danek, Zdenek Hola, Veronika Bartosova, Michaela Jarkovsky, Jiri Dusek, Ladislav Borilova Linhartova, Petra Candida species and selected behavioral factors co-associated with severe early childhood caries: Case-control study |
title |
Candida species and selected behavioral factors co-associated with severe early childhood caries: Case-control study |
title_full |
Candida species and selected behavioral factors co-associated with severe early childhood caries: Case-control study |
title_fullStr |
Candida species and selected behavioral factors co-associated with severe early childhood caries: Case-control study |
title_full_unstemmed |
Candida species and selected behavioral factors co-associated with severe early childhood caries: Case-control study |
title_short |
Candida species and selected behavioral factors co-associated with severe early childhood caries: Case-control study |
title_sort | candida species and selected behavioral factors co-associated with severe early childhood caries: case-control study |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357982/ https://www.ncbi.nlm.nih.gov/pubmed/35959372 http://dx.doi.org/10.3389/fcimb.2022.943480 |
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