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A CRISPR-guided mutagenic DNA polymerase strategy for the detection of antibiotic-resistant mutations in M. tuberculosis

A sharp increase in multidrug-resistant tuberculosis (MDR-TB) threatens human health. Spontaneous mutation in essential gene confers an ability of Mycobacterium tuberculosis resistance to anti-TB drugs. However, conventional laboratory strategies for identification and prediction of the mutations in...

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Detalles Bibliográficos
Autores principales:	Feng, Siyuan, Liang, Lujie, Shen, Cong, Lin, Daixi, Li, Jiachen, Lyu, Lingxuan, Liang, Wanfei, Zhong, Lan-lan, Cook, Gregory M., Doi, Yohei, Chen, Cha, Tian, Guo-bao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358013/ https://www.ncbi.nlm.nih.gov/pubmed/35950213 http://dx.doi.org/10.1016/j.omtn.2022.07.004

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