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High-level production of recombinant HBcAg virus-like particles in a mathematically modelled P. pastoris GS115 Mut(+) bioreactor process under controlled residual methanol concentration

Recombinant hepatitis B core antigen (HBcAg) molecules, produced in heterologous expression systems, self-assemble into highly homogenous and non-infectious virus-like particles (VLPs) that are under extensive research for biomedical applications. HBcAg production in the methylotrophic yeast P. past...

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Detalles Bibliográficos
Autores principales:	Bolmanis, Emils, Grigs, Oskars, Kazaks, Andris, Galvanauskas, Vytautas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358087/ https://www.ncbi.nlm.nih.gov/pubmed/35939139 http://dx.doi.org/10.1007/s00449-022-02754-4

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