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The role and mechanism of TXNDC5 in diseases

Thioredoxin domain-containing protein 5 (TXNDC5) is a member of the protein disulfide isomerase (PDI) family. It can promote the formation and rearrangement of disulfide bonds, ensuring proper protein folding. TXNDC5 has three Trx-like domains, which can act independently to introduce disulfide bond...

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Detalles Bibliográficos
Autores principales: Wang, Xueling, Li, Haoran, Chang, Xiaotian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358121/
https://www.ncbi.nlm.nih.gov/pubmed/35934705
http://dx.doi.org/10.1186/s40001-022-00770-4
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author Wang, Xueling
Li, Haoran
Chang, Xiaotian
author_facet Wang, Xueling
Li, Haoran
Chang, Xiaotian
author_sort Wang, Xueling
collection PubMed
description Thioredoxin domain-containing protein 5 (TXNDC5) is a member of the protein disulfide isomerase (PDI) family. It can promote the formation and rearrangement of disulfide bonds, ensuring proper protein folding. TXNDC5 has three Trx-like domains, which can act independently to introduce disulfide bonds rapidly and disorderly. TXNDC5 is abnormally expressed in various diseases, such as cancer, rheumatoid arthritis (RA), etc. It can protect cells from oxidative stress, promote cell proliferation, inhibit apoptosis and promote the progression of disease. Aberrant expression of TXNDC5 in different diseases suggests its role in disease diagnosis. In addition, targeting TXNDC5 in the treatment of diseases has shown promising application prospects. This article reviews the structure and function of TXNDC5 as well as its role and mechanism in cancer, RA and other diseases.
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spelling pubmed-93581212022-08-09 The role and mechanism of TXNDC5 in diseases Wang, Xueling Li, Haoran Chang, Xiaotian Eur J Med Res Review Thioredoxin domain-containing protein 5 (TXNDC5) is a member of the protein disulfide isomerase (PDI) family. It can promote the formation and rearrangement of disulfide bonds, ensuring proper protein folding. TXNDC5 has three Trx-like domains, which can act independently to introduce disulfide bonds rapidly and disorderly. TXNDC5 is abnormally expressed in various diseases, such as cancer, rheumatoid arthritis (RA), etc. It can protect cells from oxidative stress, promote cell proliferation, inhibit apoptosis and promote the progression of disease. Aberrant expression of TXNDC5 in different diseases suggests its role in disease diagnosis. In addition, targeting TXNDC5 in the treatment of diseases has shown promising application prospects. This article reviews the structure and function of TXNDC5 as well as its role and mechanism in cancer, RA and other diseases. BioMed Central 2022-08-08 /pmc/articles/PMC9358121/ /pubmed/35934705 http://dx.doi.org/10.1186/s40001-022-00770-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wang, Xueling
Li, Haoran
Chang, Xiaotian
The role and mechanism of TXNDC5 in diseases
title The role and mechanism of TXNDC5 in diseases
title_full The role and mechanism of TXNDC5 in diseases
title_fullStr The role and mechanism of TXNDC5 in diseases
title_full_unstemmed The role and mechanism of TXNDC5 in diseases
title_short The role and mechanism of TXNDC5 in diseases
title_sort role and mechanism of txndc5 in diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358121/
https://www.ncbi.nlm.nih.gov/pubmed/35934705
http://dx.doi.org/10.1186/s40001-022-00770-4
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