The Analysis of SNPs’ Function in miR-21 and miR146a/b in Multiple Sclerosis and Active Lesions: An In Silico Study

Multiple sclerosis (MS) is a central nervous disorder caused by several factors. Studies have recently shown that non-coding RNA such as miRNA could participate in MS initiation, progression, and active lesion. This study aims to theoretically analyze the potential impact of single-nucleotide polymo...

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Detalles Bibliográficos
Autores principales: Moraghebi, Mahta, Negahi, Ahmad Agha, Bazireh, Homa, Abbasi, Hossein, Ahmadi, Mohsen, Sarikhani, Zohreh, Mousavi, Pegah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358209/
https://www.ncbi.nlm.nih.gov/pubmed/35958297
http://dx.doi.org/10.1177/11779322221116322
Descripción
Sumario:Multiple sclerosis (MS) is a central nervous disorder caused by several factors. Studies have recently shown that non-coding RNA such as miRNA could participate in MS initiation, progression, and active lesion. This study aims to theoretically analyze the potential impact of single-nucleotide polymorphisms (SNPs) on mir-21 and mir-146a/b, which has been previously demonstrated as MS microRNA signature. To fulfill this purpose, the SNPs were investigated for functionality through several online tools, including miRNA-SNP, SNP2-TFBS, RBP-Var, and RNAfold. Furthermore, SNPs of miR-21 and miR-146a/b that exist in pre-miRNA, mature miRNA, and promoter area were extracted; moreover, miRNA and RNA-binding protein interactions were analyzed. This article presented a list of validated SNPs that could affect the expression or function of miR-21 and miR-146a/b for the future practical study of MS and active lesions.

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