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Is there an unmet medical need for improved hearing restoration?
Hearing impairment, the most prevalent sensory deficit, affects more than 466 million people worldwide (WHO). We presently lack causative treatment for the most common form, sensorineural hearing impairment; hearing aids and cochlear implants (CI) remain the only means of hearing restoration. We eng...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358394/ https://www.ncbi.nlm.nih.gov/pubmed/35833443 http://dx.doi.org/10.15252/emmm.202215798 |
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author | Wolf, Bettina Julia Kusch, Kathrin Hunniford, Victoria Vona, Barbara Kühler, Robert Keppeler, Daniel Strenzke, Nicola Moser, Tobias |
author_facet | Wolf, Bettina Julia Kusch, Kathrin Hunniford, Victoria Vona, Barbara Kühler, Robert Keppeler, Daniel Strenzke, Nicola Moser, Tobias |
author_sort | Wolf, Bettina Julia |
collection | PubMed |
description | Hearing impairment, the most prevalent sensory deficit, affects more than 466 million people worldwide (WHO). We presently lack causative treatment for the most common form, sensorineural hearing impairment; hearing aids and cochlear implants (CI) remain the only means of hearing restoration. We engaged with CI users to learn about their expectations and their willingness to collaborate with health care professionals on establishing novel therapies. We summarize upcoming CI innovations, gene therapies, and regenerative approaches and evaluate the chances for clinical translation of these novel strategies. We conclude that there remains an unmet medical need for improving hearing restoration and that we are likely to witness the clinical translation of gene therapy and major CI innovations within this decade. |
format | Online Article Text |
id | pubmed-9358394 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93583942022-08-09 Is there an unmet medical need for improved hearing restoration? Wolf, Bettina Julia Kusch, Kathrin Hunniford, Victoria Vona, Barbara Kühler, Robert Keppeler, Daniel Strenzke, Nicola Moser, Tobias EMBO Mol Med Review Hearing impairment, the most prevalent sensory deficit, affects more than 466 million people worldwide (WHO). We presently lack causative treatment for the most common form, sensorineural hearing impairment; hearing aids and cochlear implants (CI) remain the only means of hearing restoration. We engaged with CI users to learn about their expectations and their willingness to collaborate with health care professionals on establishing novel therapies. We summarize upcoming CI innovations, gene therapies, and regenerative approaches and evaluate the chances for clinical translation of these novel strategies. We conclude that there remains an unmet medical need for improving hearing restoration and that we are likely to witness the clinical translation of gene therapy and major CI innovations within this decade. John Wiley and Sons Inc. 2022-07-14 /pmc/articles/PMC9358394/ /pubmed/35833443 http://dx.doi.org/10.15252/emmm.202215798 Text en © 2022 The Authors. Published under the terms of the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Wolf, Bettina Julia Kusch, Kathrin Hunniford, Victoria Vona, Barbara Kühler, Robert Keppeler, Daniel Strenzke, Nicola Moser, Tobias Is there an unmet medical need for improved hearing restoration? |
title | Is there an unmet medical need for improved hearing restoration? |
title_full | Is there an unmet medical need for improved hearing restoration? |
title_fullStr | Is there an unmet medical need for improved hearing restoration? |
title_full_unstemmed | Is there an unmet medical need for improved hearing restoration? |
title_short | Is there an unmet medical need for improved hearing restoration? |
title_sort | is there an unmet medical need for improved hearing restoration? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358394/ https://www.ncbi.nlm.nih.gov/pubmed/35833443 http://dx.doi.org/10.15252/emmm.202215798 |
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