Functional immunity against SARS-CoV-2 in the general population after a booster campaign and the Delta and Omicron waves, Switzerland, March 2022

Functional immunity (defined here as serum neutralising capacity) critically contributes to conferring protection against SARS-CoV-2 infection and severe COVID-19. This cross-sectional analysis of a prospective, population-based cohort study included 1,894 randomly-selected 16 to 99-year-old partici...

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Autores principales: Amati, Rebecca, Frei, Anja, Kaufmann, Marco, Sabatini, Serena, Pellaton, Céline, Fehr, Jan, Albanese, Emiliano, Puhan, Milo A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2022
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358404/
https://www.ncbi.nlm.nih.gov/pubmed/35929427
http://dx.doi.org/10.2807/1560-7917.ES.2022.27.31.2200561
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author Amati, Rebecca
Frei, Anja
Kaufmann, Marco
Sabatini, Serena
Pellaton, Céline
Fehr, Jan
Albanese, Emiliano
Puhan, Milo A
author_facet Amati, Rebecca
Frei, Anja
Kaufmann, Marco
Sabatini, Serena
Pellaton, Céline
Fehr, Jan
Albanese, Emiliano
Puhan, Milo A
author_sort Amati, Rebecca
collection PubMed
description Functional immunity (defined here as serum neutralising capacity) critically contributes to conferring protection against SARS-CoV-2 infection and severe COVID-19. This cross-sectional analysis of a prospective, population-based cohort study included 1,894 randomly-selected 16 to 99-year-old participants from two Swiss cantons in March 2022. Of these, 97.6% (95% CI: 96.8–98.2%) had anti-spike IgG antibodies, and neutralising capacity was respectively observed for 94%, 92% and 88% against wild-type SARS-CoV-2, Delta and Omicron variants. Studying functional immunity to inform and monitor vaccination campaigns is crucial.
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spelling pubmed-93584042022-08-30 Functional immunity against SARS-CoV-2 in the general population after a booster campaign and the Delta and Omicron waves, Switzerland, March 2022 Amati, Rebecca Frei, Anja Kaufmann, Marco Sabatini, Serena Pellaton, Céline Fehr, Jan Albanese, Emiliano Puhan, Milo A Euro Surveill Rapid Communication Functional immunity (defined here as serum neutralising capacity) critically contributes to conferring protection against SARS-CoV-2 infection and severe COVID-19. This cross-sectional analysis of a prospective, population-based cohort study included 1,894 randomly-selected 16 to 99-year-old participants from two Swiss cantons in March 2022. Of these, 97.6% (95% CI: 96.8–98.2%) had anti-spike IgG antibodies, and neutralising capacity was respectively observed for 94%, 92% and 88% against wild-type SARS-CoV-2, Delta and Omicron variants. Studying functional immunity to inform and monitor vaccination campaigns is crucial. European Centre for Disease Prevention and Control (ECDC) 2022-08-04 /pmc/articles/PMC9358404/ /pubmed/35929427 http://dx.doi.org/10.2807/1560-7917.ES.2022.27.31.2200561 Text en This article is copyright of the authors or their affiliated institutions, 2022. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Amati, Rebecca
Frei, Anja
Kaufmann, Marco
Sabatini, Serena
Pellaton, Céline
Fehr, Jan
Albanese, Emiliano
Puhan, Milo A
Functional immunity against SARS-CoV-2 in the general population after a booster campaign and the Delta and Omicron waves, Switzerland, March 2022
title Functional immunity against SARS-CoV-2 in the general population after a booster campaign and the Delta and Omicron waves, Switzerland, March 2022
title_full Functional immunity against SARS-CoV-2 in the general population after a booster campaign and the Delta and Omicron waves, Switzerland, March 2022
title_fullStr Functional immunity against SARS-CoV-2 in the general population after a booster campaign and the Delta and Omicron waves, Switzerland, March 2022
title_full_unstemmed Functional immunity against SARS-CoV-2 in the general population after a booster campaign and the Delta and Omicron waves, Switzerland, March 2022
title_short Functional immunity against SARS-CoV-2 in the general population after a booster campaign and the Delta and Omicron waves, Switzerland, March 2022
title_sort functional immunity against sars-cov-2 in the general population after a booster campaign and the delta and omicron waves, switzerland, march 2022
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358404/
https://www.ncbi.nlm.nih.gov/pubmed/35929427
http://dx.doi.org/10.2807/1560-7917.ES.2022.27.31.2200561
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