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Blockade of STAT3/IL-4 overcomes EGFR T790M-cis-L792F-induced resistance to osimertinib via suppressing M2 macrophages polarization

BACKGROUND: The mechanism of missense alteration at EGFR L792F in patients with non-small cell lung cancer resistant to osimertinib has not been sufficiently clarified. We aimed to explore the critical molecular events and coping strategies in osimertinib resistance due to acquired L792F mutation. M...

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Detalles Bibliográficos
Autores principales:	Sun, Yiting, Dong, Yiting, Liu, Xijuan, Zhang, Yundi, Bai, Hua, Duan, Jianchun, Tian, Zhihua, Yan, Xiang, Wang, Jie, Wang, Zhijie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358434/ https://www.ncbi.nlm.nih.gov/pubmed/35932642 http://dx.doi.org/10.1016/j.ebiom.2022.104200

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