Crystal structure of Trypanosoma cruzi heme peroxidase and characterization of its substrate specificity and compound I intermediate

The protozoan parasite Trypanosoma cruzi is the causative agent of American trypanosomiasis, otherwise known as Chagas disease. To survive in the host, the T. cruzi parasite needs antioxidant defense systems. One of these is a hybrid heme peroxidase, the T. cruzi ascorbate peroxidase-cytochrome c pe...

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Detalles Bibliográficos
Autores principales: Freeman, Samuel L., Skafar, Vera, Kwon, Hanna, Fielding, Alistair J., Moody, Peter C.E., Martínez, Alejandra, Issoglio, Federico M., Inchausti, Lucas, Smircich, Pablo, Zeida, Ari, Piacenza, Lucía, Radi, Rafael, Raven, Emma L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358470/
https://www.ncbi.nlm.nih.gov/pubmed/35772495
http://dx.doi.org/10.1016/j.jbc.2022.102204

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