Identification of cell type–specific correlations between ERK activity and cell viability upon treatment with ERK1/2 inhibitors

Increased MAPK signaling is a hallmark of various cancers and is a central regulator of cell survival. Direct ERK1/2 inhibition is considered a promising approach to avoid ERK1/2 reactivation caused by upstream kinases BRAF, MEK1/2, and KRAS, as well as by receptor tyrosine kinase inhibitors, but th...

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Detalles Bibliográficos
Autores principales: Lebedev, Timofey D., Khabusheva, Elmira R., Mareeva, Sofia R., Ivanenko, Karina A., Morozov, Alexey V., Spirin, Pavel V., Rubtsov, Petr M., Snezhkina, Anastasiya V., Kudryavtseva, Anna V., Sorokin, Maxim I., Buzdin, Anton A., Prassolov, Vladimir S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358475/
https://www.ncbi.nlm.nih.gov/pubmed/35787369
http://dx.doi.org/10.1016/j.jbc.2022.102226

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