Metalloprotease ADAM9 cleaves ephrin-B ligands and differentially regulates Wnt and mTOR signaling downstream of Akt kinase in colorectal cancer cells

Ephrin-B signaling has been implicated in many normal and pathological processes, including neural crest development and tumor metastasis. We showed previously that proteolysis of ephrin-B ligands by the disintegrin metalloprotease ADAM13 is necessary for canonical Wnt signal activation and neural c...

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Detalles Bibliográficos
Autores principales: Chandrasekera, Pathirennehelage, Perfetto, Mark, Lu, Congyu, Zhuo, Minghui, Bahudhanapati, Harinath, Li, Jiejing, Chen, Wei-Chih, Kulkarni, Pallavi, Christian, Laura, Liu, Jun, Yien, Yvette Y., Yu, Chundong, Wei, Shuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Accelerated Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358476/
https://www.ncbi.nlm.nih.gov/pubmed/35780836
http://dx.doi.org/10.1016/j.jbc.2022.102225

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