Outcomes of HIV Positive Children and Adolescents Initiated on Antiretroviral Treatment in Nigeria (2007-2016)

Background: This manuscript aimed to examine treatment outcomes of HIV-positive children and adolescents. Methods: We retrospectively analyzed data of a sample of patients aged 0–19 years who initiated ART (October 2007–September 2016) in participating sites in 30 states and the Federal Capital Terr...

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Detalles Bibliográficos
Autores principales: Anukam, Onyekachi, Blanco, Natalia, Jumare, Jibreel, Lo, Julia, Babatunde, Ezra, Odafe, Solomon, Onotu, Dennis, Ene, Uzoma, Fagbamigbe, Johnson, Carpenter, Deborah, Rivadeneira, Emilia D., Omoigberale, Austin I., Charurat, Manhattan, Swaminathan, Mahesh, Stafford, Kristen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358598/
https://www.ncbi.nlm.nih.gov/pubmed/35929105
http://dx.doi.org/10.1177/23259582221117009
Descripción
Sumario:Background: This manuscript aimed to examine treatment outcomes of HIV-positive children and adolescents. Methods: We retrospectively analyzed data of a sample of patients aged 0–19 years who initiated ART (October 2007–September 2016) in participating sites in 30 states and the Federal Capital Territory in Nigeria. Results: Among 4006 patients alive at the end of the follow up period, 138 (3.4%) were LTFU. Adolescents had a significantly higher risk of being LTFU than children aged 3–5 years (HR 2.47 [95% CI 1.40-4.34]). Patients with advanced disease had a significantly higher risk of being LTFU (Stage IV HR, 3.66 [95% CI: 2.00-6.68]). On average, optimal ART refill adherence was met by 67.3% of patients. Conclusion: Our findings suggest that focusing on preventing and managing advanced disease and interventions supporting adolescents when transferring to adult care is warranted.

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