Cargando…

Association of folate and vitamin B12 imbalance with adverse pregnancy outcomes among 11,549 pregnant women: An observational cohort study

OBJECTIVE: This study aimed to evaluate maternal serum levels of folate, vitamin B12, and their ratio on admission for labor and determine whether an imbalance between folate and vitamin B12, represented by a higher or lower serum folate to vitamin B12 ratio (SFVB12R), was associated with adverse pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuan, Xiaosong, Han, Xiaoya, Zhou, Wenbo, Long, Wei, Wang, Huiyan, Yu, Bin, Zhang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358651/
https://www.ncbi.nlm.nih.gov/pubmed/35958250
http://dx.doi.org/10.3389/fnut.2022.947118
_version_ 1784763979894095872
author Yuan, Xiaosong
Han, Xiaoya
Zhou, Wenbo
Long, Wei
Wang, Huiyan
Yu, Bin
Zhang, Bin
author_facet Yuan, Xiaosong
Han, Xiaoya
Zhou, Wenbo
Long, Wei
Wang, Huiyan
Yu, Bin
Zhang, Bin
author_sort Yuan, Xiaosong
collection PubMed
description OBJECTIVE: This study aimed to evaluate maternal serum levels of folate, vitamin B12, and their ratio on admission for labor and determine whether an imbalance between folate and vitamin B12, represented by a higher or lower serum folate to vitamin B12 ratio (SFVB12R), was associated with adverse pregnancy outcomes. METHODS: A retrospective cohort study of 11,549 pregnant women attending a district specialized hospital and who had serum folate (SF) and serum vitamin B12 (SVB12) levels measured at delivery was performed. The levels of SF, SVB12, and SFVB12R were defined as high (>95th percentile), normal (5–95th percentile), and low (<5th percentile). Information on pregnancy outcomes was retrieved from medical records. Linear regression was performed to examine the association of abnormal SF, SVB12, and SFVB12R levels with fetal growth indicators. Logistic regression was applied to estimate the association between abnormal SF, SVB12, and SFVB12R levels and pregnancy outcomes. RESULTS: Lower SF levels were associated with higher risks of intrahepatic cholestasis of pregnancy (ICP, OR 1.58; 95% CI 1.15–2.17), pre-eclampsia (PE, OR 1.89; 95% CI 1.28–2.81), and a lower risk of gestational diabetes mellitus (GDM, OR 0.40; 95% CI 0.23–0.70), whereas higher SVB12 levels were associated with a higher risk of ICP (OR 2.22; 95% CI 1.67–2.96), PE (OR 1.69; 95% CI 1.04-2.74), and GDM (OR 1.62; 95% CI 1.24–2.11). A higher SFVB12R increased birthweight (β 60.99; 95% CI 29.52–92.45) and was associated with a higher risk of large-for-gestational-age (LGA) newborns (OR 3.08; 95% CI 1.63–5.83); a lower SFVB12R decreased birthweight (β −43.81; 95% CI −75.62, −12.00) and was associated with a lower risk of LGA newborns (OR 0.75; 95% CI 0.56–1.00), and with higher risks of ICP (OR 2.03; 95% CI 1.54–2.67) and pregnancy-induced hypertension (PIH, OR 1.81; 95% CI 1.09–3.00). CONCLUSION: An imbalance between folate and vitamin B12, represented by a higher or lower SFVB12R before delivery, was significantly associated with adverse pregnancy outcomes (ICP/PIH/LGA).
format Online
Article
Text
id pubmed-9358651
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93586512022-08-10 Association of folate and vitamin B12 imbalance with adverse pregnancy outcomes among 11,549 pregnant women: An observational cohort study Yuan, Xiaosong Han, Xiaoya Zhou, Wenbo Long, Wei Wang, Huiyan Yu, Bin Zhang, Bin Front Nutr Nutrition OBJECTIVE: This study aimed to evaluate maternal serum levels of folate, vitamin B12, and their ratio on admission for labor and determine whether an imbalance between folate and vitamin B12, represented by a higher or lower serum folate to vitamin B12 ratio (SFVB12R), was associated with adverse pregnancy outcomes. METHODS: A retrospective cohort study of 11,549 pregnant women attending a district specialized hospital and who had serum folate (SF) and serum vitamin B12 (SVB12) levels measured at delivery was performed. The levels of SF, SVB12, and SFVB12R were defined as high (>95th percentile), normal (5–95th percentile), and low (<5th percentile). Information on pregnancy outcomes was retrieved from medical records. Linear regression was performed to examine the association of abnormal SF, SVB12, and SFVB12R levels with fetal growth indicators. Logistic regression was applied to estimate the association between abnormal SF, SVB12, and SFVB12R levels and pregnancy outcomes. RESULTS: Lower SF levels were associated with higher risks of intrahepatic cholestasis of pregnancy (ICP, OR 1.58; 95% CI 1.15–2.17), pre-eclampsia (PE, OR 1.89; 95% CI 1.28–2.81), and a lower risk of gestational diabetes mellitus (GDM, OR 0.40; 95% CI 0.23–0.70), whereas higher SVB12 levels were associated with a higher risk of ICP (OR 2.22; 95% CI 1.67–2.96), PE (OR 1.69; 95% CI 1.04-2.74), and GDM (OR 1.62; 95% CI 1.24–2.11). A higher SFVB12R increased birthweight (β 60.99; 95% CI 29.52–92.45) and was associated with a higher risk of large-for-gestational-age (LGA) newborns (OR 3.08; 95% CI 1.63–5.83); a lower SFVB12R decreased birthweight (β −43.81; 95% CI −75.62, −12.00) and was associated with a lower risk of LGA newborns (OR 0.75; 95% CI 0.56–1.00), and with higher risks of ICP (OR 2.03; 95% CI 1.54–2.67) and pregnancy-induced hypertension (PIH, OR 1.81; 95% CI 1.09–3.00). CONCLUSION: An imbalance between folate and vitamin B12, represented by a higher or lower SFVB12R before delivery, was significantly associated with adverse pregnancy outcomes (ICP/PIH/LGA). Frontiers Media S.A. 2022-07-25 /pmc/articles/PMC9358651/ /pubmed/35958250 http://dx.doi.org/10.3389/fnut.2022.947118 Text en Copyright © 2022 Yuan, Han, Zhou, Long, Wang, Yu and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Yuan, Xiaosong
Han, Xiaoya
Zhou, Wenbo
Long, Wei
Wang, Huiyan
Yu, Bin
Zhang, Bin
Association of folate and vitamin B12 imbalance with adverse pregnancy outcomes among 11,549 pregnant women: An observational cohort study
title Association of folate and vitamin B12 imbalance with adverse pregnancy outcomes among 11,549 pregnant women: An observational cohort study
title_full Association of folate and vitamin B12 imbalance with adverse pregnancy outcomes among 11,549 pregnant women: An observational cohort study
title_fullStr Association of folate and vitamin B12 imbalance with adverse pregnancy outcomes among 11,549 pregnant women: An observational cohort study
title_full_unstemmed Association of folate and vitamin B12 imbalance with adverse pregnancy outcomes among 11,549 pregnant women: An observational cohort study
title_short Association of folate and vitamin B12 imbalance with adverse pregnancy outcomes among 11,549 pregnant women: An observational cohort study
title_sort association of folate and vitamin b12 imbalance with adverse pregnancy outcomes among 11,549 pregnant women: an observational cohort study
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358651/
https://www.ncbi.nlm.nih.gov/pubmed/35958250
http://dx.doi.org/10.3389/fnut.2022.947118
work_keys_str_mv AT yuanxiaosong associationoffolateandvitaminb12imbalancewithadversepregnancyoutcomesamong11549pregnantwomenanobservationalcohortstudy
AT hanxiaoya associationoffolateandvitaminb12imbalancewithadversepregnancyoutcomesamong11549pregnantwomenanobservationalcohortstudy
AT zhouwenbo associationoffolateandvitaminb12imbalancewithadversepregnancyoutcomesamong11549pregnantwomenanobservationalcohortstudy
AT longwei associationoffolateandvitaminb12imbalancewithadversepregnancyoutcomesamong11549pregnantwomenanobservationalcohortstudy
AT wanghuiyan associationoffolateandvitaminb12imbalancewithadversepregnancyoutcomesamong11549pregnantwomenanobservationalcohortstudy
AT yubin associationoffolateandvitaminb12imbalancewithadversepregnancyoutcomesamong11549pregnantwomenanobservationalcohortstudy
AT zhangbin associationoffolateandvitaminb12imbalancewithadversepregnancyoutcomesamong11549pregnantwomenanobservationalcohortstudy