Native metabolomics identifies the rivulariapeptolide family of protease inhibitors

The identity and biological activity of most metabolites still remain unknown. A bottleneck in the exploration of metabolite structures and pharmaceutical activities is the compound purification needed for bioactivity assignments and downstream structure elucidation. To enable bioactivity-focused co...

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Detalles Bibliográficos
Autores principales: Reher, Raphael, Aron, Allegra T., Fajtová, Pavla, Stincone, Paolo, Wagner, Berenike, Pérez-Lorente, Alicia I., Liu, Chenxi, Shalom, Ido Y. Ben, Bittremieux, Wout, Wang, Mingxun, Jeong, Kyowon, Matos-Hernandez, Marie L., Alexander, Kelsey L., Caro-Diaz, Eduardo J., Naman, C. Benjamin, Scanlan, J. H. William, Hochban, Phil M. M., Diederich, Wibke E., Molina-Santiago, Carlos, Romero, Diego, Selim, Khaled A., Sass, Peter, Brötz-Oesterhelt, Heike, Hughes, Chambers C., Dorrestein, Pieter C., O’Donoghue, Anthony J., Gerwick, William H., Petras, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358669/
https://www.ncbi.nlm.nih.gov/pubmed/35941113
http://dx.doi.org/10.1038/s41467-022-32016-6

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