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Natural history of intracholecystic papillary neoplasm (ICPN): a rare case of ICPN whose natural history was closely followed by ultrasound
The natural history of intracholecystic papillary neoplasm (ICPN), especially the speed of growth from small benign to a carcinomatous lesion, is quite unrevealed. Here, we report an extremely rare case of ICPN, in which the papillary lesion was observed transforming from small and benign to maligna...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358872/ https://www.ncbi.nlm.nih.gov/pubmed/35941538 http://dx.doi.org/10.1186/s12876-022-02454-z |
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author | Koike, Daisuke Kato, Hiroyuki Asano, Yukio Ito, Masahiro Arakawa, Satoshi Kawabe, Norihiko Shimura, Masahiro Hayashi, Chihiro Ochi, Takayuki Kamio, Kenshiro Kawai, Toki Yasuoka, Hironobu Higashiguchi, Takahiko Horiguchi, Akihiko |
author_facet | Koike, Daisuke Kato, Hiroyuki Asano, Yukio Ito, Masahiro Arakawa, Satoshi Kawabe, Norihiko Shimura, Masahiro Hayashi, Chihiro Ochi, Takayuki Kamio, Kenshiro Kawai, Toki Yasuoka, Hironobu Higashiguchi, Takahiko Horiguchi, Akihiko |
author_sort | Koike, Daisuke |
collection | PubMed |
description | The natural history of intracholecystic papillary neoplasm (ICPN), especially the speed of growth from small benign to a carcinomatous lesion, is quite unrevealed. Here, we report an extremely rare case of ICPN, in which the papillary lesion was observed transforming from small and benign to malignant using abdominal ultrasound (AUS) over 2 years during routine health checks. A 44-year-old man underwent a routine health check-up. The initial AUS showed a small sessile polyp in the gallbladder, which enlarged slightly at the next AUS, a year later. In the third year, the polypoid lesion enlarged markedly, with a maximum diameter of 10 × 9 × 7 mm. Therefore, a laparoscopic cholecystectomy was performed. Microscopically, the 10 mm tumor had intracytoplasmic mucus, and a clear cytoplasm compatible with gastric-type features. Immunohistochemical analysis showed positive staining of atypical cells for MUC6 and PAS. These findings led to the diagnosis of ICPN with high-grade intraepithelial neoplasia of the gastric type. In conclusion, sessile polyps with rapid growth might be a crucial finding in the early stage of ICPN. |
format | Online Article Text |
id | pubmed-9358872 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-93588722022-08-10 Natural history of intracholecystic papillary neoplasm (ICPN): a rare case of ICPN whose natural history was closely followed by ultrasound Koike, Daisuke Kato, Hiroyuki Asano, Yukio Ito, Masahiro Arakawa, Satoshi Kawabe, Norihiko Shimura, Masahiro Hayashi, Chihiro Ochi, Takayuki Kamio, Kenshiro Kawai, Toki Yasuoka, Hironobu Higashiguchi, Takahiko Horiguchi, Akihiko BMC Gastroenterol Case Report The natural history of intracholecystic papillary neoplasm (ICPN), especially the speed of growth from small benign to a carcinomatous lesion, is quite unrevealed. Here, we report an extremely rare case of ICPN, in which the papillary lesion was observed transforming from small and benign to malignant using abdominal ultrasound (AUS) over 2 years during routine health checks. A 44-year-old man underwent a routine health check-up. The initial AUS showed a small sessile polyp in the gallbladder, which enlarged slightly at the next AUS, a year later. In the third year, the polypoid lesion enlarged markedly, with a maximum diameter of 10 × 9 × 7 mm. Therefore, a laparoscopic cholecystectomy was performed. Microscopically, the 10 mm tumor had intracytoplasmic mucus, and a clear cytoplasm compatible with gastric-type features. Immunohistochemical analysis showed positive staining of atypical cells for MUC6 and PAS. These findings led to the diagnosis of ICPN with high-grade intraepithelial neoplasia of the gastric type. In conclusion, sessile polyps with rapid growth might be a crucial finding in the early stage of ICPN. BioMed Central 2022-08-08 /pmc/articles/PMC9358872/ /pubmed/35941538 http://dx.doi.org/10.1186/s12876-022-02454-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Koike, Daisuke Kato, Hiroyuki Asano, Yukio Ito, Masahiro Arakawa, Satoshi Kawabe, Norihiko Shimura, Masahiro Hayashi, Chihiro Ochi, Takayuki Kamio, Kenshiro Kawai, Toki Yasuoka, Hironobu Higashiguchi, Takahiko Horiguchi, Akihiko Natural history of intracholecystic papillary neoplasm (ICPN): a rare case of ICPN whose natural history was closely followed by ultrasound |
title | Natural history of intracholecystic papillary neoplasm (ICPN): a rare case of ICPN whose natural history was closely followed by ultrasound |
title_full | Natural history of intracholecystic papillary neoplasm (ICPN): a rare case of ICPN whose natural history was closely followed by ultrasound |
title_fullStr | Natural history of intracholecystic papillary neoplasm (ICPN): a rare case of ICPN whose natural history was closely followed by ultrasound |
title_full_unstemmed | Natural history of intracholecystic papillary neoplasm (ICPN): a rare case of ICPN whose natural history was closely followed by ultrasound |
title_short | Natural history of intracholecystic papillary neoplasm (ICPN): a rare case of ICPN whose natural history was closely followed by ultrasound |
title_sort | natural history of intracholecystic papillary neoplasm (icpn): a rare case of icpn whose natural history was closely followed by ultrasound |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358872/ https://www.ncbi.nlm.nih.gov/pubmed/35941538 http://dx.doi.org/10.1186/s12876-022-02454-z |
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