COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivation

Immunization with two mRNA vaccine doses elicits robust spike-specific CD8(+) T cell responses, but reports of waning immunity after COVID-19 vaccination prompt the introduction of booster vaccination campaigns. However, the effect of mRNA booster vaccination on the spike-specific CD8(+) T cell resp...

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Detalles Bibliográficos
Autores principales: Reinscheid, Matthias, Luxenburger, Hendrik, Karl, Vivien, Graeser, Anne, Giese, Sebastian, Ciminski, Kevin, Reeg, David B., Oberhardt, Valerie, Roehlen, Natascha, Lang-Meli, Julia, Heim, Kathrin, Gross, Nina, Baum, Christina, Rieg, Siegbert, Speer, Claudius, Emmerich, Florian, Breisinger, Susanne, Steinmann, Daniel, Bengsch, Bertram, Boettler, Tobias, Kochs, Georg, Schwemmle, Martin, Thimme, Robert, Neumann-Haefelin, Christoph, Hofmann, Maike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358914/
https://www.ncbi.nlm.nih.gov/pubmed/35941157
http://dx.doi.org/10.1038/s41467-022-32324-x

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