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HTLV-1 intragenic viral enhancer influences immortalization phenotype in vitro, but is dispensable for persistence and disease development in animal models

Human T-cell leukemia virus type 1 (HTLV-1) is the causative infectious agent of adult T-cell leukemia/lymphoma (ATL) and chronic neurological disease. The disparity between silenced sense transcription versus constitutively active antisense (Hbz) transcription from the integrated provirus is not fu...

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Detalles Bibliográficos
Autores principales:	Maksimova, Victoria, Smith, Susan, Seth, Jaideep, Phelps, Cameron, Niewiesk, Stefan, Satou, Yorifumi, Green, Patrick L., Panfil, Amanda R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359075/ https://www.ncbi.nlm.nih.gov/pubmed/35958554 http://dx.doi.org/10.3389/fimmu.2022.954077

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