Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin

Aspirin prevents thrombosis by inhibiting platelet cyclooxygenase (COX)-1 activity and the production of thromboxane (Tx)A(2), a pro-thrombotic eicosanoid. However, the non-platelet actions of aspirin limit its antithrombotic effects. Here, we used platelet-COX-1-ko mice to define the platelet and n...

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Detalles Bibliográficos
Autores principales: Crescente, Marilena, Armstrong, Paul C., Kirkby, Nicholas S., Edin, Matthew L., Chan, Melissa V., Lih, Fred B., Jiao, Jing, Maffucci, Tania, Allan, Harriet E., Mein, Charles A., Gaston-Massuet, Carles, Cottrell, Graeme S., Mitchell, Jane A., Zeldin, Darryl C., Herschman, Harvey R., Warner, Timothy D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359103/
https://www.ncbi.nlm.nih.gov/pubmed/32592197
http://dx.doi.org/10.1096/fj.202000312R

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