An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entry

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and related sarbecoviruses enter host cells by receptor-recognition and membrane-fusion. An indispensable step in fusion is the formation of 6-helix bundle by viral spike heptad repeats 1 and 2 (HR1 and HR2). Here, we report the constructi...

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Detalles Bibliográficos
Autores principales: Lin, Xi, Guo, Liyan, Lin, Sheng, Chen, Zimin, Yang, Fanli, Yang, Jing, Wang, Lingling, Wen, Ao, Duan, Yanping, Zhang, Xindan, Dai, Yushan, Yin, Keqing, Yuan, Xin, Yu, Chongzhang, He, Bin, Cao, Yu, Dong, Haohao, Li, Jian, Zhao, Qi, Lu, Guangwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Coronaviruses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359175/
https://www.ncbi.nlm.nih.gov/pubmed/35757908
http://dx.doi.org/10.1080/22221751.2022.2095308

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