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Clinical and mycological profile of fungal keratitis from North and North-East India

PURPOSE: To study the clinical presentation, mycological profile, and risk factors of fungal keratitis (FK) cases presenting at two tertiary-care centers, one each at North (Chandigarh) and Northeast (Assam) India, and to compare the spectrum of fungi recovered from the clinical and environmental sa...

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Autores principales: Tawde, Yamini, Singh, Shreya, Das, Sourav, Rudramurthy, Shivaprakash M, Kaur, Harsimran, Gupta, Amit, Kataki, Mounjuri, Gogoi, Pranami, Ghosh, Anup K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359279/
https://www.ncbi.nlm.nih.gov/pubmed/35647967
http://dx.doi.org/10.4103/ijo.IJO_1602_21
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author Tawde, Yamini
Singh, Shreya
Das, Sourav
Rudramurthy, Shivaprakash M
Kaur, Harsimran
Gupta, Amit
Kataki, Mounjuri
Gogoi, Pranami
Ghosh, Anup K
author_facet Tawde, Yamini
Singh, Shreya
Das, Sourav
Rudramurthy, Shivaprakash M
Kaur, Harsimran
Gupta, Amit
Kataki, Mounjuri
Gogoi, Pranami
Ghosh, Anup K
author_sort Tawde, Yamini
collection PubMed
description PURPOSE: To study the clinical presentation, mycological profile, and risk factors of fungal keratitis (FK) cases presenting at two tertiary-care centers, one each at North (Chandigarh) and Northeast (Assam) India, and to compare the spectrum of fungi recovered from the clinical and environmental samples at both locations. METHODS: All patients with suspected FK were enrolled from both the centers between January 2018 and December 2019. Corneal samples were collected and processed as per standard laboratory protocols. Demographic details and clinical and mycological profiles were noted in all patients. Environmental sampling from the soil, air, and the vegetative matter was performed from both locations and neighboring districts. RESULTS: Of the 475 suspected cases, 337 (71%) were diagnosed as FK (median age: 50 years; 77.2% males). The presence of diabetes, hypertension, blurred vision, and corneal discoloration was significantly higher in patients with FK compared to those without FK. Aspergillus sp. (52.1%) and Fusarium sp. (47.61%) were the predominant etiological agents isolated from cases in North and Northeast India, respectively. FK due to melanized fungi was associated with diabetes, trauma with animal tail, and corneal discoloration. A similar spectrum of fungi was seen in environmental and clinical samples in both the regions. CONCLUSION: The difference in etiological agents of FK and environmental fungal isolates in North and Northeast India highlights the need to identify the ecological niche of potential fungal pathogens. Prospective, multicenter studies, systematic environmental sampling, and the evaluation of the differences in causative agents and clinical presentation of FK from different parts of the country can substantially improve our understanding of its region-specific clinico-epidemiological profile.
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spelling pubmed-93592792022-08-10 Clinical and mycological profile of fungal keratitis from North and North-East India Tawde, Yamini Singh, Shreya Das, Sourav Rudramurthy, Shivaprakash M Kaur, Harsimran Gupta, Amit Kataki, Mounjuri Gogoi, Pranami Ghosh, Anup K Indian J Ophthalmol Original Article PURPOSE: To study the clinical presentation, mycological profile, and risk factors of fungal keratitis (FK) cases presenting at two tertiary-care centers, one each at North (Chandigarh) and Northeast (Assam) India, and to compare the spectrum of fungi recovered from the clinical and environmental samples at both locations. METHODS: All patients with suspected FK were enrolled from both the centers between January 2018 and December 2019. Corneal samples were collected and processed as per standard laboratory protocols. Demographic details and clinical and mycological profiles were noted in all patients. Environmental sampling from the soil, air, and the vegetative matter was performed from both locations and neighboring districts. RESULTS: Of the 475 suspected cases, 337 (71%) were diagnosed as FK (median age: 50 years; 77.2% males). The presence of diabetes, hypertension, blurred vision, and corneal discoloration was significantly higher in patients with FK compared to those without FK. Aspergillus sp. (52.1%) and Fusarium sp. (47.61%) were the predominant etiological agents isolated from cases in North and Northeast India, respectively. FK due to melanized fungi was associated with diabetes, trauma with animal tail, and corneal discoloration. A similar spectrum of fungi was seen in environmental and clinical samples in both the regions. CONCLUSION: The difference in etiological agents of FK and environmental fungal isolates in North and Northeast India highlights the need to identify the ecological niche of potential fungal pathogens. Prospective, multicenter studies, systematic environmental sampling, and the evaluation of the differences in causative agents and clinical presentation of FK from different parts of the country can substantially improve our understanding of its region-specific clinico-epidemiological profile. Wolters Kluwer - Medknow 2022-06 2022-05-31 /pmc/articles/PMC9359279/ /pubmed/35647967 http://dx.doi.org/10.4103/ijo.IJO_1602_21 Text en Copyright: © 2022 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Tawde, Yamini
Singh, Shreya
Das, Sourav
Rudramurthy, Shivaprakash M
Kaur, Harsimran
Gupta, Amit
Kataki, Mounjuri
Gogoi, Pranami
Ghosh, Anup K
Clinical and mycological profile of fungal keratitis from North and North-East India
title Clinical and mycological profile of fungal keratitis from North and North-East India
title_full Clinical and mycological profile of fungal keratitis from North and North-East India
title_fullStr Clinical and mycological profile of fungal keratitis from North and North-East India
title_full_unstemmed Clinical and mycological profile of fungal keratitis from North and North-East India
title_short Clinical and mycological profile of fungal keratitis from North and North-East India
title_sort clinical and mycological profile of fungal keratitis from north and north-east india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359279/
https://www.ncbi.nlm.nih.gov/pubmed/35647967
http://dx.doi.org/10.4103/ijo.IJO_1602_21
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