Accelerated stability testing of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin A poisoning

The current study evaluated the stability potential of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary rel...

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Detalles Bibliográficos
Autores principales: Banerjee, Subham, Chattopadhyay, Pronobesh, Ghosh, Animesh, Bhattacharya, Shiv Sankar, Kundu, Amit, Veer, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359325/
http://dx.doi.org/10.1016/j.jfda.2014.01.022
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author Banerjee, Subham
Chattopadhyay, Pronobesh
Ghosh, Animesh
Bhattacharya, Shiv Sankar
Kundu, Amit
Veer, Vijay
author_facet Banerjee, Subham
Chattopadhyay, Pronobesh
Ghosh, Animesh
Bhattacharya, Shiv Sankar
Kundu, Amit
Veer, Vijay
author_sort Banerjee, Subham
collection PubMed
description The current study evaluated the stability potential of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary release liner. Stability testing of the optimized formulation was established for 6 months under accelerated study conditions as per International Conference on Harmonisation guidelines. Results obtained after 6 months showed that the optimized patch formulation was stable with respect to drugs content, pH, diffusion, visual inspection, and other analytical parameters.
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spelling pubmed-93593252022-08-09 Accelerated stability testing of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin A poisoning Banerjee, Subham Chattopadhyay, Pronobesh Ghosh, Animesh Bhattacharya, Shiv Sankar Kundu, Amit Veer, Vijay J Food Drug Anal Original Article The current study evaluated the stability potential of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary release liner. Stability testing of the optimized formulation was established for 6 months under accelerated study conditions as per International Conference on Harmonisation guidelines. Results obtained after 6 months showed that the optimized patch formulation was stable with respect to drugs content, pH, diffusion, visual inspection, and other analytical parameters. Taiwan Food and Drug Administration 2014-02-14 /pmc/articles/PMC9359325/ http://dx.doi.org/10.1016/j.jfda.2014.01.022 Text en © 2014 Taiwan Food and Drug Administration https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Original Article
Banerjee, Subham
Chattopadhyay, Pronobesh
Ghosh, Animesh
Bhattacharya, Shiv Sankar
Kundu, Amit
Veer, Vijay
Accelerated stability testing of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin A poisoning
title Accelerated stability testing of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin A poisoning
title_full Accelerated stability testing of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin A poisoning
title_fullStr Accelerated stability testing of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin A poisoning
title_full_unstemmed Accelerated stability testing of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin A poisoning
title_short Accelerated stability testing of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin A poisoning
title_sort accelerated stability testing of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin a poisoning
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359325/
http://dx.doi.org/10.1016/j.jfda.2014.01.022
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