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The Flavagline Compound 1-(2-(dimethylamino)acetyl)-Rocaglaol Induces Apoptosis in K562 Cells by Regulating the PI3K/Akt/mTOR, JAK2/STAT3, and MAPK Pathways

PURPOSE: Chronic myelogenous leukemia (CML) is a hematological malignancy with increased proliferation of cells of the myeloid series. This can disrupt normal hematopoiesis. The 1-(2-(dimethylamino)acetyl)-rocaglaol (MQ-16) is a new synthetic flavagline compound that showed promising activity in chr...

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Detalles Bibliográficos
Autores principales:	Yang, Xinmei, Wu, Xijun, Wu, Xiaosen, Huang, Lei, Song, Jingrui, Yuan, Chunmao, He, Zhixu, Li, Yanmei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359389/ https://www.ncbi.nlm.nih.gov/pubmed/35959422 http://dx.doi.org/10.2147/DDDT.S357891

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