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Upward trends of syphilis in the non-pregnant adults: A six-year report on clinical and epidemiological profile of syphilis from a tertiary care center, India

Since 2000, a resurgence of syphilis has been noted in many developed and developing countries, especially among men who have sex with men (MSM). Incidence and prevalence of syphilis in pregnant women have been reduced drastically by mandatory screening in early pregnancy. Insufficient data in other...

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Autores principales: Solaimalai, Dhanalakshmi, Gupta, Ankan, George, Leni, Manesh, Abi, Karthik, Rajiv, Sathishkumar, Dharshini, Peter, C. V Dincy, Varghese, George M, Pulimood, Susanne A, Kannangai, Rajesh, Prakash, John AJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359669/
https://www.ncbi.nlm.nih.gov/pubmed/35958862
http://dx.doi.org/10.3389/fpubh.2022.908591
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author Solaimalai, Dhanalakshmi
Gupta, Ankan
George, Leni
Manesh, Abi
Karthik, Rajiv
Sathishkumar, Dharshini
Peter, C. V Dincy
Varghese, George M
Pulimood, Susanne A
Kannangai, Rajesh
Prakash, John AJ
author_facet Solaimalai, Dhanalakshmi
Gupta, Ankan
George, Leni
Manesh, Abi
Karthik, Rajiv
Sathishkumar, Dharshini
Peter, C. V Dincy
Varghese, George M
Pulimood, Susanne A
Kannangai, Rajesh
Prakash, John AJ
author_sort Solaimalai, Dhanalakshmi
collection PubMed
description Since 2000, a resurgence of syphilis has been noted in many developed and developing countries, especially among men who have sex with men (MSM). Incidence and prevalence of syphilis in pregnant women have been reduced drastically by mandatory screening in early pregnancy. Insufficient data in other populations especially from developing countries limit targeted public health interventions. This study aimed to describe the clinical and epidemiological profile of serologically confirmed syphilis cases among the non-pregnant high-risk group reporting to a tertiary care center in Southern India. A retrospective study was carried out in a tertiary care center in Southern India for 6 years from 2015 to 2020. A total of 265 serologically confirmed syphilis patients were included. A statistically significant increase in positivity from 0.52 to 2.1% was observed in this study (2015 to 2020). Among risk factors, high-risk behavior with multiple heterosexual partners was the commonest (51.3%), followed by marital partners who tested positive (9.4%) and MSM (7.5%). The majority of the patients were diagnosed at the latent stage (79%), followed by secondary syphilis (10%) and tertiary syphilis (8%). A quarter of patients (23%) were coinfected with HIV. Serological non-responsiveness was more common among HIV infected (47 vs. 24%). Sixteen had neurosyphilis and six had ocular involvement. HIV co-infection complicated 50% (8/16) of neurosyphilis patients. Syphilis is still prevalent, especially in high-risk groups including those are attending STI clinics. Further prospective multicentric studies are needed to identify and implement public health measures.
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spelling pubmed-93596692022-08-10 Upward trends of syphilis in the non-pregnant adults: A six-year report on clinical and epidemiological profile of syphilis from a tertiary care center, India Solaimalai, Dhanalakshmi Gupta, Ankan George, Leni Manesh, Abi Karthik, Rajiv Sathishkumar, Dharshini Peter, C. V Dincy Varghese, George M Pulimood, Susanne A Kannangai, Rajesh Prakash, John AJ Front Public Health Public Health Since 2000, a resurgence of syphilis has been noted in many developed and developing countries, especially among men who have sex with men (MSM). Incidence and prevalence of syphilis in pregnant women have been reduced drastically by mandatory screening in early pregnancy. Insufficient data in other populations especially from developing countries limit targeted public health interventions. This study aimed to describe the clinical and epidemiological profile of serologically confirmed syphilis cases among the non-pregnant high-risk group reporting to a tertiary care center in Southern India. A retrospective study was carried out in a tertiary care center in Southern India for 6 years from 2015 to 2020. A total of 265 serologically confirmed syphilis patients were included. A statistically significant increase in positivity from 0.52 to 2.1% was observed in this study (2015 to 2020). Among risk factors, high-risk behavior with multiple heterosexual partners was the commonest (51.3%), followed by marital partners who tested positive (9.4%) and MSM (7.5%). The majority of the patients were diagnosed at the latent stage (79%), followed by secondary syphilis (10%) and tertiary syphilis (8%). A quarter of patients (23%) were coinfected with HIV. Serological non-responsiveness was more common among HIV infected (47 vs. 24%). Sixteen had neurosyphilis and six had ocular involvement. HIV co-infection complicated 50% (8/16) of neurosyphilis patients. Syphilis is still prevalent, especially in high-risk groups including those are attending STI clinics. Further prospective multicentric studies are needed to identify and implement public health measures. Frontiers Media S.A. 2022-07-26 /pmc/articles/PMC9359669/ /pubmed/35958862 http://dx.doi.org/10.3389/fpubh.2022.908591 Text en Copyright © 2022 Solaimalai, Gupta, George, Manesh, Karthik, Sathishkumar, Peter, Varghese, Pulimood, Kannangai and Prakash. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Solaimalai, Dhanalakshmi
Gupta, Ankan
George, Leni
Manesh, Abi
Karthik, Rajiv
Sathishkumar, Dharshini
Peter, C. V Dincy
Varghese, George M
Pulimood, Susanne A
Kannangai, Rajesh
Prakash, John AJ
Upward trends of syphilis in the non-pregnant adults: A six-year report on clinical and epidemiological profile of syphilis from a tertiary care center, India
title Upward trends of syphilis in the non-pregnant adults: A six-year report on clinical and epidemiological profile of syphilis from a tertiary care center, India
title_full Upward trends of syphilis in the non-pregnant adults: A six-year report on clinical and epidemiological profile of syphilis from a tertiary care center, India
title_fullStr Upward trends of syphilis in the non-pregnant adults: A six-year report on clinical and epidemiological profile of syphilis from a tertiary care center, India
title_full_unstemmed Upward trends of syphilis in the non-pregnant adults: A six-year report on clinical and epidemiological profile of syphilis from a tertiary care center, India
title_short Upward trends of syphilis in the non-pregnant adults: A six-year report on clinical and epidemiological profile of syphilis from a tertiary care center, India
title_sort upward trends of syphilis in the non-pregnant adults: a six-year report on clinical and epidemiological profile of syphilis from a tertiary care center, india
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359669/
https://www.ncbi.nlm.nih.gov/pubmed/35958862
http://dx.doi.org/10.3389/fpubh.2022.908591
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