Transient Inhibition of the JAK/STAT Pathway Prevents B-ALL Development in Genetically Predisposed Mice

Preventing development of childhood B-cell acute lymphoblastic leukemia (B-ALL), a disease with devastating effects, is a longstanding and unsolved challenge. Heterozygous germline alterations in the PAX5 gene can lead to B-ALL upon accumulation of secondary mutations affecting the JAK/STAT signalin...

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Detalles Bibliográficos
Autores principales: Casado-García, Ana, Isidro-Hernández, Marta, Oak, Ninad, Mayado, Andrea, Mann-Ran, Christine, Raboso-Gallego, Javier, Alemán-Arteaga, Silvia, Buhles, Alexandra, Sterker, Dario, Sánchez, Elena G., Martínez-Cano, Jorge, Blanco, Oscar, Orfao, Alberto, Alonso-López, Diego, De Las Rivas, Javier, Riesco, Susana, Prieto-Matos, Pablo, González-Murillo, África, García Criado, Francisco Javier, García Cenador, María Begoña, Radimerski, Thomas, Ramírez-Orellana, Manuel, Cobaleda, César, Yang, Jun J., Vicente-Dueñas, Carolina, Weiss, Andreas, Nichols, Kim E., Sánchez-García, Isidro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Translational Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359729/
https://www.ncbi.nlm.nih.gov/pubmed/35131871
http://dx.doi.org/10.1158/0008-5472.CAN-21-3386

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