In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy of the bile ducts within the liver characterized by high levels of genetic heterogeneity. In the context of such genetic variability, determining which oncogenic mutations drive ICC growth has been difficult, and developing modes of p...

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Detalles Bibliográficos
Autores principales: Younger, Nicholas T., Wilson, Mollie L., Martinez Lyons, Anabel, Jarman, Edward J., Meynert, Alison M., Grimes, Graeme R., Gournopanos, Konstantinos, Waddell, Scott H., Tennant, Peter A., Wilson, David H., Guest, Rachel V., Wigmore, Stephen J., Acosta, Juan Carlos, Kendall, Timothy J., Taylor, Martin S., Sproul, Duncan, Mill, Pleasantine, Boulter, Luke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Molecular Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359731/
https://www.ncbi.nlm.nih.gov/pubmed/35074757
http://dx.doi.org/10.1158/0008-5472.CAN-21-2556

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