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Combined Inactivation of CTPS1 and ATR Is Synthetically Lethal to MYC-Overexpressing Cancer Cells

The “undruggable” oncogene MYC supports cancer cell proliferation and survival through parallel induction of multiple anabolic processes. Here we find that inhibiting CTP synthase (CTPS) selectively decreases cell viability and induces DNA replication stress in MYC-overexpressing cells. MYC-driven r...

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Detalles Bibliográficos
Autores principales:	Sun, Zhe, Zhang, Ziheng, Wang, Qiao-Qi, Liu, Ji-Long
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Molecular Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359733/ https://www.ncbi.nlm.nih.gov/pubmed/35022212 http://dx.doi.org/10.1158/0008-5472.CAN-21-1707

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