Effect of Single-dose Azithromycin on Pneumococcal Carriage and Resistance: A Randomized Controlled Trial

We evaluated antibiotic resistance selection in Streptococcus pneumoniae isolates from children participating in an individually randomized trial of single-dose azithromycin versus placebo. After 14 days, the prevalence of resistance to erythromycin, oxacillin, and clindamycin was elevated in the az...

Descripción completa

Detalles Bibliográficos
Autores principales: Coulibaly, Boubacar, Kiemde, Dramane, Zonou, Guillaume, Sié, Ali, Dah, Clarisse, Bountogo, Mamadou, Brogdon, Jessica, Hu, Huiyu, Lebas, Elodie, Porco, Travis C., Doan, Thuy, Lietman, Thomas M., Oldenburg, Catherine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Antimicrobial Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359759/
https://www.ncbi.nlm.nih.gov/pubmed/35944061
http://dx.doi.org/10.1097/INF.0000000000003585
_version_ 1784764202109370368
author Coulibaly, Boubacar
Kiemde, Dramane
Zonou, Guillaume
Sié, Ali
Dah, Clarisse
Bountogo, Mamadou
Brogdon, Jessica
Hu, Huiyu
Lebas, Elodie
Porco, Travis C.
Doan, Thuy
Lietman, Thomas M.
Oldenburg, Catherine E.
author_facet Coulibaly, Boubacar
Kiemde, Dramane
Zonou, Guillaume
Sié, Ali
Dah, Clarisse
Bountogo, Mamadou
Brogdon, Jessica
Hu, Huiyu
Lebas, Elodie
Porco, Travis C.
Doan, Thuy
Lietman, Thomas M.
Oldenburg, Catherine E.
author_sort Coulibaly, Boubacar
collection PubMed
description We evaluated antibiotic resistance selection in Streptococcus pneumoniae isolates from children participating in an individually randomized trial of single-dose azithromycin versus placebo. After 14 days, the prevalence of resistance to erythromycin, oxacillin, and clindamycin was elevated in the azithromycin versus placebo group. There was no difference at 6 months.
format Online
Article
Text
id pubmed-9359759
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-93597592022-08-11 Effect of Single-dose Azithromycin on Pneumococcal Carriage and Resistance: A Randomized Controlled Trial Coulibaly, Boubacar Kiemde, Dramane Zonou, Guillaume Sié, Ali Dah, Clarisse Bountogo, Mamadou Brogdon, Jessica Hu, Huiyu Lebas, Elodie Porco, Travis C. Doan, Thuy Lietman, Thomas M. Oldenburg, Catherine E. Pediatr Infect Dis J Antimicrobial Reports We evaluated antibiotic resistance selection in Streptococcus pneumoniae isolates from children participating in an individually randomized trial of single-dose azithromycin versus placebo. After 14 days, the prevalence of resistance to erythromycin, oxacillin, and clindamycin was elevated in the azithromycin versus placebo group. There was no difference at 6 months. Lippincott Williams & Wilkins 2022-05-23 2022-09 /pmc/articles/PMC9359759/ /pubmed/35944061 http://dx.doi.org/10.1097/INF.0000000000003585 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Antimicrobial Reports
Coulibaly, Boubacar
Kiemde, Dramane
Zonou, Guillaume
Sié, Ali
Dah, Clarisse
Bountogo, Mamadou
Brogdon, Jessica
Hu, Huiyu
Lebas, Elodie
Porco, Travis C.
Doan, Thuy
Lietman, Thomas M.
Oldenburg, Catherine E.
Effect of Single-dose Azithromycin on Pneumococcal Carriage and Resistance: A Randomized Controlled Trial
title Effect of Single-dose Azithromycin on Pneumococcal Carriage and Resistance: A Randomized Controlled Trial
title_full Effect of Single-dose Azithromycin on Pneumococcal Carriage and Resistance: A Randomized Controlled Trial
title_fullStr Effect of Single-dose Azithromycin on Pneumococcal Carriage and Resistance: A Randomized Controlled Trial
title_full_unstemmed Effect of Single-dose Azithromycin on Pneumococcal Carriage and Resistance: A Randomized Controlled Trial
title_short Effect of Single-dose Azithromycin on Pneumococcal Carriage and Resistance: A Randomized Controlled Trial
title_sort effect of single-dose azithromycin on pneumococcal carriage and resistance: a randomized controlled trial
topic Antimicrobial Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359759/
https://www.ncbi.nlm.nih.gov/pubmed/35944061
http://dx.doi.org/10.1097/INF.0000000000003585
work_keys_str_mv AT coulibalyboubacar effectofsingledoseazithromycinonpneumococcalcarriageandresistancearandomizedcontrolledtrial
AT kiemdedramane effectofsingledoseazithromycinonpneumococcalcarriageandresistancearandomizedcontrolledtrial
AT zonouguillaume effectofsingledoseazithromycinonpneumococcalcarriageandresistancearandomizedcontrolledtrial
AT sieali effectofsingledoseazithromycinonpneumococcalcarriageandresistancearandomizedcontrolledtrial
AT dahclarisse effectofsingledoseazithromycinonpneumococcalcarriageandresistancearandomizedcontrolledtrial
AT bountogomamadou effectofsingledoseazithromycinonpneumococcalcarriageandresistancearandomizedcontrolledtrial
AT brogdonjessica effectofsingledoseazithromycinonpneumococcalcarriageandresistancearandomizedcontrolledtrial
AT huhuiyu effectofsingledoseazithromycinonpneumococcalcarriageandresistancearandomizedcontrolledtrial
AT lebaselodie effectofsingledoseazithromycinonpneumococcalcarriageandresistancearandomizedcontrolledtrial
AT porcotravisc effectofsingledoseazithromycinonpneumococcalcarriageandresistancearandomizedcontrolledtrial
AT doanthuy effectofsingledoseazithromycinonpneumococcalcarriageandresistancearandomizedcontrolledtrial
AT lietmanthomasm effectofsingledoseazithromycinonpneumococcalcarriageandresistancearandomizedcontrolledtrial
AT oldenburgcatherinee effectofsingledoseazithromycinonpneumococcalcarriageandresistancearandomizedcontrolledtrial

Ejemplares similares