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Therapeutic Efficacy of Great Plantain (Plantago major L.) in the Treatment of Second-Degree Burn Wounds: A Case-Control Study

BACKGROUND: Great plantain (Plantago major L. or P.major) is a medicinal plant that is available all around the world. The whole plant has several bioactive compounds including terpenoids, flavonoids, phenolic compounds, alkaloids, fatty acids, iridoid glycosides, polysaccharides, and vitamins. Scie...

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Autores principales: Keshavarzi, Abdolkhalegh, Montaseri, Hashem, Akrami, Rahimeh, Moradi Sarvestani, Hossein, Khosravi, Fateme, Foolad, Sara, Zardosht, Mitra, Zareie, Saeid, Saharkhiz, Mohammad Jamal, Shahriarirad, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359829/
https://www.ncbi.nlm.nih.gov/pubmed/35966146
http://dx.doi.org/10.1155/2022/4923277
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author Keshavarzi, Abdolkhalegh
Montaseri, Hashem
Akrami, Rahimeh
Moradi Sarvestani, Hossein
Khosravi, Fateme
Foolad, Sara
Zardosht, Mitra
Zareie, Saeid
Saharkhiz, Mohammad Jamal
Shahriarirad, Reza
author_facet Keshavarzi, Abdolkhalegh
Montaseri, Hashem
Akrami, Rahimeh
Moradi Sarvestani, Hossein
Khosravi, Fateme
Foolad, Sara
Zardosht, Mitra
Zareie, Saeid
Saharkhiz, Mohammad Jamal
Shahriarirad, Reza
author_sort Keshavarzi, Abdolkhalegh
collection PubMed
description BACKGROUND: Great plantain (Plantago major L. or P.major) is a medicinal plant that is available all around the world. The whole plant has several bioactive compounds including terpenoids, flavonoids, phenolic compounds, alkaloids, fatty acids, iridoid glycosides, polysaccharides, and vitamins. Scientific studies have recognized several medical benefits like wound healing, anti-inflammatory, antimicrobial, antiulcerative, and antioxidative agents. The wound-healing capacity of this plant has been investigated under in vivo and ex vivo conditions. In the current study, we aim to compare the therapeutic effect of the P.major extract with 1% sulfadiazine on the healing of second-degree burn wounds. METHOD: Second-degree burn victims were included in our study. The investigation and control group, respectively, received P. major ointment 10% and silver sulfadiazine ointment 1%. The bacterial culture from the wound site was taken on days 3, 7, 10, 13, and last day of hospitalization. Patients' subjective complaints were obtained through the visual analog scale (VAS). All patients were treated and evaluated in the hospital. RESULT: Among the 15 patients, 11 were male, and the mean age was 33.3 years. The average complete healing duration was 11.73 vs. 13 days in the P. major and control group, respectively (P=0.166). On the third day, infection control was similar between the two groups, and on the seventh day, all bacterial cultures were negative. Although there was a significant reduction in pain scores during the recovery time, no significant differences in pain reduction were noted between the two groups (P=0.849). CONCLUSION: We showed that P.major ointment is a safe and suitable herbal compound in the treatment of second-degree burn wounds that not only has wound-healing properties but also is an analgesic and antimicrobial compound.
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spelling pubmed-93598292022-08-12 Therapeutic Efficacy of Great Plantain (Plantago major L.) in the Treatment of Second-Degree Burn Wounds: A Case-Control Study Keshavarzi, Abdolkhalegh Montaseri, Hashem Akrami, Rahimeh Moradi Sarvestani, Hossein Khosravi, Fateme Foolad, Sara Zardosht, Mitra Zareie, Saeid Saharkhiz, Mohammad Jamal Shahriarirad, Reza Int J Clin Pract Research Article BACKGROUND: Great plantain (Plantago major L. or P.major) is a medicinal plant that is available all around the world. The whole plant has several bioactive compounds including terpenoids, flavonoids, phenolic compounds, alkaloids, fatty acids, iridoid glycosides, polysaccharides, and vitamins. Scientific studies have recognized several medical benefits like wound healing, anti-inflammatory, antimicrobial, antiulcerative, and antioxidative agents. The wound-healing capacity of this plant has been investigated under in vivo and ex vivo conditions. In the current study, we aim to compare the therapeutic effect of the P.major extract with 1% sulfadiazine on the healing of second-degree burn wounds. METHOD: Second-degree burn victims were included in our study. The investigation and control group, respectively, received P. major ointment 10% and silver sulfadiazine ointment 1%. The bacterial culture from the wound site was taken on days 3, 7, 10, 13, and last day of hospitalization. Patients' subjective complaints were obtained through the visual analog scale (VAS). All patients were treated and evaluated in the hospital. RESULT: Among the 15 patients, 11 were male, and the mean age was 33.3 years. The average complete healing duration was 11.73 vs. 13 days in the P. major and control group, respectively (P=0.166). On the third day, infection control was similar between the two groups, and on the seventh day, all bacterial cultures were negative. Although there was a significant reduction in pain scores during the recovery time, no significant differences in pain reduction were noted between the two groups (P=0.849). CONCLUSION: We showed that P.major ointment is a safe and suitable herbal compound in the treatment of second-degree burn wounds that not only has wound-healing properties but also is an analgesic and antimicrobial compound. Hindawi 2022-08-01 /pmc/articles/PMC9359829/ /pubmed/35966146 http://dx.doi.org/10.1155/2022/4923277 Text en Copyright © 2022 Abdolkhalegh Keshavarzi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Keshavarzi, Abdolkhalegh
Montaseri, Hashem
Akrami, Rahimeh
Moradi Sarvestani, Hossein
Khosravi, Fateme
Foolad, Sara
Zardosht, Mitra
Zareie, Saeid
Saharkhiz, Mohammad Jamal
Shahriarirad, Reza
Therapeutic Efficacy of Great Plantain (Plantago major L.) in the Treatment of Second-Degree Burn Wounds: A Case-Control Study
title Therapeutic Efficacy of Great Plantain (Plantago major L.) in the Treatment of Second-Degree Burn Wounds: A Case-Control Study
title_full Therapeutic Efficacy of Great Plantain (Plantago major L.) in the Treatment of Second-Degree Burn Wounds: A Case-Control Study
title_fullStr Therapeutic Efficacy of Great Plantain (Plantago major L.) in the Treatment of Second-Degree Burn Wounds: A Case-Control Study
title_full_unstemmed Therapeutic Efficacy of Great Plantain (Plantago major L.) in the Treatment of Second-Degree Burn Wounds: A Case-Control Study
title_short Therapeutic Efficacy of Great Plantain (Plantago major L.) in the Treatment of Second-Degree Burn Wounds: A Case-Control Study
title_sort therapeutic efficacy of great plantain (plantago major l.) in the treatment of second-degree burn wounds: a case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359829/
https://www.ncbi.nlm.nih.gov/pubmed/35966146
http://dx.doi.org/10.1155/2022/4923277
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