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Clinical Effect of Renal Arterial Sympathetic Radiofrequency Ablation on Secondary Hypertension

Sympathetic hyperactivity is one of the main mechanisms of secondary hypertension. Reducing renal sympathetic activity through surgery can effectively reduce blood pressure. Many cases have shown that renal denervation (RDN) can selectively block renal artery sympathetic nerve activity to control re...

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Autores principales: Zhang, Hui, Huang, Ting, Shen, Jie, Zou, Yuanlin, Deng, Yunchao, Hou, Min, Huang, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359839/
https://www.ncbi.nlm.nih.gov/pubmed/35959345
http://dx.doi.org/10.1155/2022/9948057
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author Zhang, Hui
Huang, Ting
Shen, Jie
Zou, Yuanlin
Deng, Yunchao
Hou, Min
Huang, Xiang
author_facet Zhang, Hui
Huang, Ting
Shen, Jie
Zou, Yuanlin
Deng, Yunchao
Hou, Min
Huang, Xiang
author_sort Zhang, Hui
collection PubMed
description Sympathetic hyperactivity is one of the main mechanisms of secondary hypertension. Reducing renal sympathetic activity through surgery can effectively reduce blood pressure. Many cases have shown that renal denervation (RDN) can selectively block renal artery sympathetic nerve activity to control refractory hypertension. This surgery is a minimally invasive surgery, and the risk of surgery-related adverse events is significantly reduced compared with surgery. Therefore, the purpose of this study is to explore the efficacy of radiofrequency ablation of renal artery sympathetic nerve in the treatment of secondary hypertension. Eight patients with secondary hypertension diagnosed by the cardiovascular department of our hospital and treated with RDN were followed up for 3-18 months, of which 5 cases were followed up for more than 12 months and 8 cases were followed up for more than 3 months. Eight patients were treated with radiofrequency ablation of renal artery catheter. The parameters such as preoperative blood pressure, antihypertensive drugs, organ function, intraoperative ablation resistance, power, time, and temperature were determined. The related changes of blood pressure, antihypertensive drugs, and visceral function and the occurrence of side effects at 1 week and 1, 3, 6, and 12 months after operation were related to the operation. In conclusion, RDN has a significant clinical effect in the treatment of refractory hypertension, with stable postoperative blood pressure drop, reduced drug dosage, and less side effects.
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spelling pubmed-93598392022-08-10 Clinical Effect of Renal Arterial Sympathetic Radiofrequency Ablation on Secondary Hypertension Zhang, Hui Huang, Ting Shen, Jie Zou, Yuanlin Deng, Yunchao Hou, Min Huang, Xiang Comput Math Methods Med Research Article Sympathetic hyperactivity is one of the main mechanisms of secondary hypertension. Reducing renal sympathetic activity through surgery can effectively reduce blood pressure. Many cases have shown that renal denervation (RDN) can selectively block renal artery sympathetic nerve activity to control refractory hypertension. This surgery is a minimally invasive surgery, and the risk of surgery-related adverse events is significantly reduced compared with surgery. Therefore, the purpose of this study is to explore the efficacy of radiofrequency ablation of renal artery sympathetic nerve in the treatment of secondary hypertension. Eight patients with secondary hypertension diagnosed by the cardiovascular department of our hospital and treated with RDN were followed up for 3-18 months, of which 5 cases were followed up for more than 12 months and 8 cases were followed up for more than 3 months. Eight patients were treated with radiofrequency ablation of renal artery catheter. The parameters such as preoperative blood pressure, antihypertensive drugs, organ function, intraoperative ablation resistance, power, time, and temperature were determined. The related changes of blood pressure, antihypertensive drugs, and visceral function and the occurrence of side effects at 1 week and 1, 3, 6, and 12 months after operation were related to the operation. In conclusion, RDN has a significant clinical effect in the treatment of refractory hypertension, with stable postoperative blood pressure drop, reduced drug dosage, and less side effects. Hindawi 2022-08-01 /pmc/articles/PMC9359839/ /pubmed/35959345 http://dx.doi.org/10.1155/2022/9948057 Text en Copyright © 2022 Hui Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Hui
Huang, Ting
Shen, Jie
Zou, Yuanlin
Deng, Yunchao
Hou, Min
Huang, Xiang
Clinical Effect of Renal Arterial Sympathetic Radiofrequency Ablation on Secondary Hypertension
title Clinical Effect of Renal Arterial Sympathetic Radiofrequency Ablation on Secondary Hypertension
title_full Clinical Effect of Renal Arterial Sympathetic Radiofrequency Ablation on Secondary Hypertension
title_fullStr Clinical Effect of Renal Arterial Sympathetic Radiofrequency Ablation on Secondary Hypertension
title_full_unstemmed Clinical Effect of Renal Arterial Sympathetic Radiofrequency Ablation on Secondary Hypertension
title_short Clinical Effect of Renal Arterial Sympathetic Radiofrequency Ablation on Secondary Hypertension
title_sort clinical effect of renal arterial sympathetic radiofrequency ablation on secondary hypertension
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359839/
https://www.ncbi.nlm.nih.gov/pubmed/35959345
http://dx.doi.org/10.1155/2022/9948057
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