Mesoderm-derived PDGFRA(+) cells regulate the emergence of hematopoietic stem cells in the dorsal aorta

Mouse haematopoietic stem cells (HSCs) first emerge at embryonic day 10.5 (E10.5), on the ventral surface of the dorsal aorta, by endothelial-to-haematopoietic transition. We investigated whether mesenchymal stem cells, which provide an essential niche for long-term HSCs (LT-HSCs) in the bone marrow...

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Detalles Bibliográficos
Autores principales: Chandrakanthan, Vashe, Rorimpandey, Prunella, Zanini, Fabio, Chacon, Diego, Olivier, Jake, Joshi, Swapna, Kang, Young Chan, Knezevic, Kathy, Huang, Yizhou, Qiao, Qiao, Oliver, Rema A., Unnikrishnan, Ashwin, Carter, Daniel R., Lee, Brendan, Brownlee, Chris, Power, Carl, Brink, Robert, Mendez-Ferrer, Simon, Enikolopov, Grigori, Walsh, William, Göttgens, Berthold, Taoudi, Samir, Beck, Dominik, Pimanda, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359911/
https://www.ncbi.nlm.nih.gov/pubmed/35902769
http://dx.doi.org/10.1038/s41556-022-00955-3

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