Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3

Amycolatopsis sp. MST-135876 was isolated from soil collected from the riverbank of El Pont de Suert, Catalonia, Spain. Cultivation of MST-135876 on a range of media led to the discovery of a previously unreported dichlorinated cyclic hexapeptide, suertide A (d-Ser, 5-Cl-d-Trp, 6-Cl-d-Trp, l-Ile, d-...

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Detalles Bibliográficos
Autores principales: Lacey, Heather J., Chen, Rachel, Vuong, Daniel, Fisher, Mark F., Lacey, Ernest, Rutledge, Peter J., Piggott, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359914/
https://www.ncbi.nlm.nih.gov/pubmed/35882958
http://dx.doi.org/10.1038/s41429-022-00544-4
Descripción
Sumario:Amycolatopsis sp. MST-135876 was isolated from soil collected from the riverbank of El Pont de Suert, Catalonia, Spain. Cultivation of MST-135876 on a range of media led to the discovery of a previously unreported dichlorinated cyclic hexapeptide, suertide A (d-Ser, 5-Cl-d-Trp, 6-Cl-d-Trp, l-Ile, d-Val, d-Glu), featuring an unprecedented pair of adjacent 5/6-chlorotryptophan residues. Supplementing the growth medium with KBr resulted in production of the mono- and dibrominated analogues suertides B and C, respectively. Suertides A–C displayed selective activity against Bacillus subtilis (MIC 1.6 µg ml(−1)) and Staphylococcus aureus (MIC 3.1, 6.3, and 12.5 µg ml(−1), respectively), while suertides A and B showed appreciable activity against methicillin-resistant S. aureus (MIC 1.6 and 6.3 µg ml(−1), respectively).

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