Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3

Amycolatopsis sp. MST-135876 was isolated from soil collected from the riverbank of El Pont de Suert, Catalonia, Spain. Cultivation of MST-135876 on a range of media led to the discovery of a previously unreported dichlorinated cyclic hexapeptide, suertide A (d-Ser, 5-Cl-d-Trp, 6-Cl-d-Trp, l-Ile, d-...

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Autores principales: Lacey, Heather J., Chen, Rachel, Vuong, Daniel, Fisher, Mark F., Lacey, Ernest, Rutledge, Peter J., Piggott, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359914/
https://www.ncbi.nlm.nih.gov/pubmed/35882958
http://dx.doi.org/10.1038/s41429-022-00544-4
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author Lacey, Heather J.
Chen, Rachel
Vuong, Daniel
Fisher, Mark F.
Lacey, Ernest
Rutledge, Peter J.
Piggott, Andrew M.
author_facet Lacey, Heather J.
Chen, Rachel
Vuong, Daniel
Fisher, Mark F.
Lacey, Ernest
Rutledge, Peter J.
Piggott, Andrew M.
author_sort Lacey, Heather J.
collection PubMed
description Amycolatopsis sp. MST-135876 was isolated from soil collected from the riverbank of El Pont de Suert, Catalonia, Spain. Cultivation of MST-135876 on a range of media led to the discovery of a previously unreported dichlorinated cyclic hexapeptide, suertide A (d-Ser, 5-Cl-d-Trp, 6-Cl-d-Trp, l-Ile, d-Val, d-Glu), featuring an unprecedented pair of adjacent 5/6-chlorotryptophan residues. Supplementing the growth medium with KBr resulted in production of the mono- and dibrominated analogues suertides B and C, respectively. Suertides A–C displayed selective activity against Bacillus subtilis (MIC 1.6 µg ml(−1)) and Staphylococcus aureus (MIC 3.1, 6.3, and 12.5 µg ml(−1), respectively), while suertides A and B showed appreciable activity against methicillin-resistant S. aureus (MIC 1.6 and 6.3 µg ml(−1), respectively).
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spelling pubmed-93599142022-08-10 Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3 Lacey, Heather J. Chen, Rachel Vuong, Daniel Fisher, Mark F. Lacey, Ernest Rutledge, Peter J. Piggott, Andrew M. J Antibiot (Tokyo) Article Amycolatopsis sp. MST-135876 was isolated from soil collected from the riverbank of El Pont de Suert, Catalonia, Spain. Cultivation of MST-135876 on a range of media led to the discovery of a previously unreported dichlorinated cyclic hexapeptide, suertide A (d-Ser, 5-Cl-d-Trp, 6-Cl-d-Trp, l-Ile, d-Val, d-Glu), featuring an unprecedented pair of adjacent 5/6-chlorotryptophan residues. Supplementing the growth medium with KBr resulted in production of the mono- and dibrominated analogues suertides B and C, respectively. Suertides A–C displayed selective activity against Bacillus subtilis (MIC 1.6 µg ml(−1)) and Staphylococcus aureus (MIC 3.1, 6.3, and 12.5 µg ml(−1), respectively), while suertides A and B showed appreciable activity against methicillin-resistant S. aureus (MIC 1.6 and 6.3 µg ml(−1), respectively). Nature Publishing Group UK 2022-07-26 2022 /pmc/articles/PMC9359914/ /pubmed/35882958 http://dx.doi.org/10.1038/s41429-022-00544-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lacey, Heather J.
Chen, Rachel
Vuong, Daniel
Fisher, Mark F.
Lacey, Ernest
Rutledge, Peter J.
Piggott, Andrew M.
Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3
title Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3
title_full Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3
title_fullStr Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3
title_full_unstemmed Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3
title_short Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3
title_sort suertides a–c: selective antibacterial cyclic hexapeptides from amycolatopsis sp. mst-135876v3
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359914/
https://www.ncbi.nlm.nih.gov/pubmed/35882958
http://dx.doi.org/10.1038/s41429-022-00544-4
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