Nucleotide imbalance decouples cell growth from cell proliferation

Nucleotide metabolism supports RNA synthesis and DNA replication to enable cell growth and division. Nucleotide depletion can inhibit cell growth and proliferation, but how cells sense and respond to changes in the relative levels of individual nucleotides is unclear. Moreover, the nucleotide requir...

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Detalles Bibliográficos
Autores principales: Diehl, Frances F., Miettinen, Teemu P., Elbashir, Ryan, Nabel, Christopher S., Darnell, Alicia M., Do, Brian T., Manalis, Scott R., Lewis, Caroline A., Vander Heiden, Matthew G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359916/
https://www.ncbi.nlm.nih.gov/pubmed/35927450
http://dx.doi.org/10.1038/s41556-022-00965-1

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