A 33-residue peptide tag increases solubility and stability of Escherichia coli produced single-chain antibody fragments

Single-chain variable fragments (scFvs), composed of variable domains of heavy and light chains of an antibody joined by a linker, share antigen binding capacity with their parental antibody. Due to intrinsically low solubility and stability, only two Escherichia coli-produced scFvs have been approv...

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Detalles Bibliográficos
Autores principales: Wang, Yang, Yuan, Wenjie, Guo, Siqi, Li, Qiqi, Chen, Xiaomei, Li, Cheng, Liu, Qianying, Sun, Lei, Chen, Zhenguo, Yuan, Zhenghong, Luo, Cheng, Chen, Shijie, Tong, Shuping, Nassal, Michael, Wen, Yu-Mei, Wang, Yong-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359998/
https://www.ncbi.nlm.nih.gov/pubmed/35941164
http://dx.doi.org/10.1038/s41467-022-32423-9

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