OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways

Deubiquitinating enzymes (DUBs) regulate numerous cellular functions by removing ubiquitin modifications. We examined the effects of 88 human DUBs on linear ubiquitin chain assembly complex (LUBAC)-induced NF-κB activation, and identified OTUD1 as a potent suppressor. OTUD1 regulates the canonical N...

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Detalles Bibliográficos
Autores principales: Oikawa, Daisuke, Gi, Min, Kosako, Hidetaka, Shimizu, Kouhei, Takahashi, Hirotaka, Shiota, Masayuki, Hosomi, Shuhei, Komakura, Keidai, Wanibuchi, Hideki, Tsuruta, Daisuke, Sawasaki, Tatsuya, Tokunaga, Fuminori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360000/
https://www.ncbi.nlm.nih.gov/pubmed/35941131
http://dx.doi.org/10.1038/s41419-022-05145-5

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