Lack of full sequencing GBA1 studies for patients with Parkinson’s disease in Latin America

Full sequencing of the GBA1 gene in patients with Parkinson’s disease provides a wide screening of pathogenic variants, but less developed regions of the world, like Latin America, may have difficulties in performing full sequencing. We performed a systematic review with meta-analysis to explore the...

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Detalles Bibliográficos
Autores principales: Santos-Lobato, Bruno Lopes, Schumacher-Schuh, Artur F., Mata, Ignacio F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360049/
https://www.ncbi.nlm.nih.gov/pubmed/35941142
http://dx.doi.org/10.1038/s41531-022-00358-z
Descripción
Sumario:Full sequencing of the GBA1 gene in patients with Parkinson’s disease provides a wide screening of pathogenic variants, but less developed regions of the world, like Latin America, may have difficulties in performing full sequencing. We performed a systematic review with meta-analysis to explore the prevalence and the odds ratio of specific GBA1 variants in Parkinson’s disease in Latin America. We noted a lack of full sequencing GBA1 studies in Latin America.

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