Lack of full sequencing GBA1 studies for patients with Parkinson’s disease in Latin America

Full sequencing of the GBA1 gene in patients with Parkinson’s disease provides a wide screening of pathogenic variants, but less developed regions of the world, like Latin America, may have difficulties in performing full sequencing. We performed a systematic review with meta-analysis to explore the...

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Detalles Bibliográficos
Autores principales: Santos-Lobato, Bruno Lopes, Schumacher-Schuh, Artur F., Mata, Ignacio F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360049/
https://www.ncbi.nlm.nih.gov/pubmed/35941142
http://dx.doi.org/10.1038/s41531-022-00358-z
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author Santos-Lobato, Bruno Lopes
Schumacher-Schuh, Artur F.
Mata, Ignacio F.
author_facet Santos-Lobato, Bruno Lopes
Schumacher-Schuh, Artur F.
Mata, Ignacio F.
author_sort Santos-Lobato, Bruno Lopes
collection PubMed
description Full sequencing of the GBA1 gene in patients with Parkinson’s disease provides a wide screening of pathogenic variants, but less developed regions of the world, like Latin America, may have difficulties in performing full sequencing. We performed a systematic review with meta-analysis to explore the prevalence and the odds ratio of specific GBA1 variants in Parkinson’s disease in Latin America. We noted a lack of full sequencing GBA1 studies in Latin America.
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spelling pubmed-93600492022-08-10 Lack of full sequencing GBA1 studies for patients with Parkinson’s disease in Latin America Santos-Lobato, Bruno Lopes Schumacher-Schuh, Artur F. Mata, Ignacio F. NPJ Parkinsons Dis Brief Communication Full sequencing of the GBA1 gene in patients with Parkinson’s disease provides a wide screening of pathogenic variants, but less developed regions of the world, like Latin America, may have difficulties in performing full sequencing. We performed a systematic review with meta-analysis to explore the prevalence and the odds ratio of specific GBA1 variants in Parkinson’s disease in Latin America. We noted a lack of full sequencing GBA1 studies in Latin America. Nature Publishing Group UK 2022-08-08 /pmc/articles/PMC9360049/ /pubmed/35941142 http://dx.doi.org/10.1038/s41531-022-00358-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Santos-Lobato, Bruno Lopes
Schumacher-Schuh, Artur F.
Mata, Ignacio F.
Lack of full sequencing GBA1 studies for patients with Parkinson’s disease in Latin America
title Lack of full sequencing GBA1 studies for patients with Parkinson’s disease in Latin America
title_full Lack of full sequencing GBA1 studies for patients with Parkinson’s disease in Latin America
title_fullStr Lack of full sequencing GBA1 studies for patients with Parkinson’s disease in Latin America
title_full_unstemmed Lack of full sequencing GBA1 studies for patients with Parkinson’s disease in Latin America
title_short Lack of full sequencing GBA1 studies for patients with Parkinson’s disease in Latin America
title_sort lack of full sequencing gba1 studies for patients with parkinson’s disease in latin america
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360049/
https://www.ncbi.nlm.nih.gov/pubmed/35941142
http://dx.doi.org/10.1038/s41531-022-00358-z
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