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Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease

INTRODUCTION: The apolipoprotein E (APOE) ɛ2 allele reduces risk against Alzheimer's disease (AD) but mechanisms underlying this effect are largely unknown. METHODS: We conducted a genome‐wide association study for AD among 2096 ɛ2 carriers. The potential role of the top‐ranked gene and complem...

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Detalles Bibliográficos
Autores principales:	Jun, Gyungah R., You, Yang, Zhu, Congcong, Meng, Gaoyuan, Chung, Jaeyoon, Panitch, Rebecca, Hu, Junming, Xia, Weiming, Bennett, David A., Foroud, Tatiana M., Wang, Li‐San, Haines, Jonathan L., Mayeux, Richard, Pericak‐Vance, Margaret A., Schellenberg, Gerard D., Au, Rhoda, Lunetta, Kathryn L., Ikezu, Tsuneya, Stein, Thor D., Farrer, Lindsay A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Featured Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360190/ https://www.ncbi.nlm.nih.gov/pubmed/35142023 http://dx.doi.org/10.1002/alz.12607

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