The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model

The P522R variant of PLCG2, expressed by microglia, is associated with reduced risk of Alzheimer's disease (AD). Yet, the impact of this protective mutation on microglial responses to AD pathology remains unknown. Chimeric AD and wild‐type mice were generated by transplanting PLCG2‐P522R or iso...

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Autores principales: Claes, Christel, England, Whitney E., Danhash, Emma P., Kiani Shabestari, Sepideh, Jairaman, Amit, Chadarevian, Jean Paul, Hasselmann, Jonathan, Tsai, Andy P., Coburn, Morgan A., Sanchez, Jessica, Lim, Tau En, Hidalgo, Jorge L. S., Tu, Christina, Cahalan, Michael D., Lamb, Bruce T., Landreth, Gary E., Spitale, Robert C., Blurton‐Jones, Mathew, Davtyan, Hayk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360195/
https://www.ncbi.nlm.nih.gov/pubmed/35142046
http://dx.doi.org/10.1002/alz.12577

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