RNA editing facilitates the enhanced production of neoantigens during the simultaneous administration of oxaliplatin and radiotherapy in colorectal cancer

Most cases of colorectal cancers (CRCs) are microsatellite stable (MSS), which frequently demonstrate lower response rates to immune checkpoint inhibitors (ICIs). RNA editing produces neoantigens by altering amino acid sequences. In this study, RNA editing was induced artificially by chemoradiation...

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Detalles Bibliográficos
Autores principales: Komatsu, Yasuhiro, Shigeyasu, Kunitoshi, Yano, Shuya, Takeda, Sho, Takahashi, Kazutaka, Hata, Nanako, Umeda, Hibiki, Yoshida, Kazuhiro, Mori, Yoshiko, Yasui, Kazuya, Yoshida, Ryuichi, Kondo, Yoshitaka, Kishimoto, Hiroyuki, Teraishi, Fuminori, Umeda, Yuzo, Kagawa, Shunsuke, Michiue, Hiroyuki, Tazawa, Hiroshi, Goel, Ajay, Fujiwara, Toshiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360398/
https://www.ncbi.nlm.nih.gov/pubmed/35941214
http://dx.doi.org/10.1038/s41598-022-17773-0

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