Alterations to the broad-spectrum formin inhibitor SMIFH2 modulate potency but not specificity

SMIFH2 is a small molecule inhibitor of the formin family of cytoskeletal regulators that was originally identified in a screen for suppression of actin polymerization induced by the mouse formin Diaphanous 1 (mDia1). Despite widespread use of this compound, it is unknown whether SMIFH2 inhibits all...

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Detalles Bibliográficos
Autores principales: Orman, Marina, Landis, Maya, Oza, Aisha, Nambiar, Deepika, Gjeci, Joana, Song, Kristen, Huang, Vivian, Klestzick, Amanda, Hachicho, Carla, Liu, Su Qing, Kamm, Judith M., Bartolini, Francesca, Vadakkan, Jean J., Rojas, Christian M., Vizcarra, Christina L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360399/
https://www.ncbi.nlm.nih.gov/pubmed/35941181
http://dx.doi.org/10.1038/s41598-022-17685-z

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