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A neural circuit for wind-guided olfactory navigation

To navigate towards a food source, animals frequently combine odor cues about source identity with wind direction cues about source location. Where and how these two cues are integrated to support navigation is unclear. Here we describe a pathway to the Drosophila fan-shaped body that encodes attrac...

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Autores principales: Matheson, Andrew M. M., Lanz, Aaron J., Medina, Ashley M., Licata, Al M., Currier, Timothy A., Syed, Mubarak H., Nagel, Katherine I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360402/
https://www.ncbi.nlm.nih.gov/pubmed/35941114
http://dx.doi.org/10.1038/s41467-022-32247-7
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author Matheson, Andrew M. M.
Lanz, Aaron J.
Medina, Ashley M.
Licata, Al M.
Currier, Timothy A.
Syed, Mubarak H.
Nagel, Katherine I.
author_facet Matheson, Andrew M. M.
Lanz, Aaron J.
Medina, Ashley M.
Licata, Al M.
Currier, Timothy A.
Syed, Mubarak H.
Nagel, Katherine I.
author_sort Matheson, Andrew M. M.
collection PubMed
description To navigate towards a food source, animals frequently combine odor cues about source identity with wind direction cues about source location. Where and how these two cues are integrated to support navigation is unclear. Here we describe a pathway to the Drosophila fan-shaped body that encodes attractive odor and promotes upwind navigation. We show that neurons throughout this pathway encode odor, but not wind direction. Using connectomics, we identify fan-shaped body local neurons called h∆C that receive input from this odor pathway and a previously described wind pathway. We show that h∆C neurons exhibit odor-gated, wind direction-tuned activity, that sparse activation of h∆C neurons promotes navigation in a reproducible direction, and that h∆C activity is required for persistent upwind orientation during odor. Based on connectome data, we develop a computational model showing how h∆C activity can promote navigation towards a goal such as an upwind odor source. Our results suggest that odor and wind cues are processed by separate pathways and integrated within the fan-shaped body to support goal-directed navigation.
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spelling pubmed-93604022022-08-10 A neural circuit for wind-guided olfactory navigation Matheson, Andrew M. M. Lanz, Aaron J. Medina, Ashley M. Licata, Al M. Currier, Timothy A. Syed, Mubarak H. Nagel, Katherine I. Nat Commun Article To navigate towards a food source, animals frequently combine odor cues about source identity with wind direction cues about source location. Where and how these two cues are integrated to support navigation is unclear. Here we describe a pathway to the Drosophila fan-shaped body that encodes attractive odor and promotes upwind navigation. We show that neurons throughout this pathway encode odor, but not wind direction. Using connectomics, we identify fan-shaped body local neurons called h∆C that receive input from this odor pathway and a previously described wind pathway. We show that h∆C neurons exhibit odor-gated, wind direction-tuned activity, that sparse activation of h∆C neurons promotes navigation in a reproducible direction, and that h∆C activity is required for persistent upwind orientation during odor. Based on connectome data, we develop a computational model showing how h∆C activity can promote navigation towards a goal such as an upwind odor source. Our results suggest that odor and wind cues are processed by separate pathways and integrated within the fan-shaped body to support goal-directed navigation. Nature Publishing Group UK 2022-08-08 /pmc/articles/PMC9360402/ /pubmed/35941114 http://dx.doi.org/10.1038/s41467-022-32247-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Matheson, Andrew M. M.
Lanz, Aaron J.
Medina, Ashley M.
Licata, Al M.
Currier, Timothy A.
Syed, Mubarak H.
Nagel, Katherine I.
A neural circuit for wind-guided olfactory navigation
title A neural circuit for wind-guided olfactory navigation
title_full A neural circuit for wind-guided olfactory navigation
title_fullStr A neural circuit for wind-guided olfactory navigation
title_full_unstemmed A neural circuit for wind-guided olfactory navigation
title_short A neural circuit for wind-guided olfactory navigation
title_sort neural circuit for wind-guided olfactory navigation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360402/
https://www.ncbi.nlm.nih.gov/pubmed/35941114
http://dx.doi.org/10.1038/s41467-022-32247-7
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