Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody

Agonist-induced phosphorylation of G protein-coupled receptors (GPCRs) is a primary determinant of β-arrestin (βarr) recruitment and trafficking. For several GPCRs such as the vasopressin receptor subtype 2 (V(2)R), agonist-stimulation first drives the translocation of βarrs to the plasma membrane,...

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Detalles Bibliográficos
Autores principales: Baidya, Mithu, Chaturvedi, Madhu, Dwivedi-Agnihotri, Hemlata, Ranjan, Ashutosh, Devost, Dominic, Namkung, Yoon, Stepniewski, Tomasz Maciej, Pandey, Shubhi, Baruah, Minakshi, Panigrahi, Bhanupriya, Sarma, Parishmita, Yadav, Manish K., Maharana, Jagannath, Banerjee, Ramanuj, Kawakami, Kouki, Inoue, Asuka, Selent, Jana, Laporte, Stéphane A., Hébert, Terence E., Shukla, Arun K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360436/
https://www.ncbi.nlm.nih.gov/pubmed/35941121
http://dx.doi.org/10.1038/s41467-022-32386-x

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