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Evaluating carbon-electrode dielectrophoresis under the ASSURED criteria
Extreme point-of-care refers to medical testing in unfavorable conditions characterized by a lack of primary resources or infrastructure. As witnessed in the recent past, considerable interest in developing devices and technologies exists for extreme point-of-care applications, for which the World H...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360481/ https://www.ncbi.nlm.nih.gov/pubmed/35958120 http://dx.doi.org/10.3389/fmedt.2022.922737 |
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author | Martinez-Duarte, Rodrigo Mager, Dario Korvink, Jan G. Islam, Monsur |
author_facet | Martinez-Duarte, Rodrigo Mager, Dario Korvink, Jan G. Islam, Monsur |
author_sort | Martinez-Duarte, Rodrigo |
collection | PubMed |
description | Extreme point-of-care refers to medical testing in unfavorable conditions characterized by a lack of primary resources or infrastructure. As witnessed in the recent past, considerable interest in developing devices and technologies exists for extreme point-of-care applications, for which the World Health Organization has introduced a set of encouraging and regulating guidelines. These are referred to as the ASSURED criteria, an acronym for Affordable (A), Sensitive (S), Specific (S), User friendly (U), Rapid and Robust (R), Equipment-free (E), and Delivered (D). However, the current extreme point of care devices may require an intermediate sample preparation step for performing complex biomedical analysis, including the diagnosis of rare-cell diseases and early-stage detection of sepsis. This article assesses the potential of carbon-electrode dielectrophoresis (CarbonDEP) for sample preparation competent in extreme point-of-care, following the ASSURED criteria. We first discuss the theory and utility of dielectrophoresis (DEP) and the advantages of using carbon microelectrodes for this purpose. We then critically review the literature relevant to the use of CarbonDEP for bioparticle manipulation under the scope of the ASSURED criteria. Lastly, we offer a perspective on the roadmap needed to strengthen the use of CarbonDEP in extreme point-of-care applications. |
format | Online Article Text |
id | pubmed-9360481 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93604812022-08-10 Evaluating carbon-electrode dielectrophoresis under the ASSURED criteria Martinez-Duarte, Rodrigo Mager, Dario Korvink, Jan G. Islam, Monsur Front Med Technol Medical Technology Extreme point-of-care refers to medical testing in unfavorable conditions characterized by a lack of primary resources or infrastructure. As witnessed in the recent past, considerable interest in developing devices and technologies exists for extreme point-of-care applications, for which the World Health Organization has introduced a set of encouraging and regulating guidelines. These are referred to as the ASSURED criteria, an acronym for Affordable (A), Sensitive (S), Specific (S), User friendly (U), Rapid and Robust (R), Equipment-free (E), and Delivered (D). However, the current extreme point of care devices may require an intermediate sample preparation step for performing complex biomedical analysis, including the diagnosis of rare-cell diseases and early-stage detection of sepsis. This article assesses the potential of carbon-electrode dielectrophoresis (CarbonDEP) for sample preparation competent in extreme point-of-care, following the ASSURED criteria. We first discuss the theory and utility of dielectrophoresis (DEP) and the advantages of using carbon microelectrodes for this purpose. We then critically review the literature relevant to the use of CarbonDEP for bioparticle manipulation under the scope of the ASSURED criteria. Lastly, we offer a perspective on the roadmap needed to strengthen the use of CarbonDEP in extreme point-of-care applications. Frontiers Media S.A. 2022-07-26 /pmc/articles/PMC9360481/ /pubmed/35958120 http://dx.doi.org/10.3389/fmedt.2022.922737 Text en Copyright © 2022 Martinez-Duarte, Mager, Korvink and Islam. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medical Technology Martinez-Duarte, Rodrigo Mager, Dario Korvink, Jan G. Islam, Monsur Evaluating carbon-electrode dielectrophoresis under the ASSURED criteria |
title | Evaluating carbon-electrode dielectrophoresis under the ASSURED criteria |
title_full | Evaluating carbon-electrode dielectrophoresis under the ASSURED criteria |
title_fullStr | Evaluating carbon-electrode dielectrophoresis under the ASSURED criteria |
title_full_unstemmed | Evaluating carbon-electrode dielectrophoresis under the ASSURED criteria |
title_short | Evaluating carbon-electrode dielectrophoresis under the ASSURED criteria |
title_sort | evaluating carbon-electrode dielectrophoresis under the assured criteria |
topic | Medical Technology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360481/ https://www.ncbi.nlm.nih.gov/pubmed/35958120 http://dx.doi.org/10.3389/fmedt.2022.922737 |
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