The emerging roles of PHOSPHO1 and its regulated phospholipid homeostasis in metabolic disorders

Emerging evidence suggests that phosphoethanolamine/phosphocholine phosphatase 1 (PHOSPHO1), a specific phosphoethanolamine and phosphocholine phosphatase, is involved in energy metabolism. In this review, we describe the structure and regulation of PHOSPHO1, as well as current knowledge about the r...

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Autores principales: Liu, Yi, Wu, Yingting, Jiang, Mengxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360546/
https://www.ncbi.nlm.nih.gov/pubmed/35957983
http://dx.doi.org/10.3389/fphys.2022.935195
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author Liu, Yi
Wu, Yingting
Jiang, Mengxi
author_facet Liu, Yi
Wu, Yingting
Jiang, Mengxi
author_sort Liu, Yi
collection PubMed
description Emerging evidence suggests that phosphoethanolamine/phosphocholine phosphatase 1 (PHOSPHO1), a specific phosphoethanolamine and phosphocholine phosphatase, is involved in energy metabolism. In this review, we describe the structure and regulation of PHOSPHO1, as well as current knowledge about the role of PHOSPHO1 and its related phospholipid metabolites in regulating energy metabolism. We also examine mechanistic evidence of PHOSPHO1- and phospholipid-mediated regulation of mitochondrial and lipid droplets functions in the context of metabolic homeostasis, which could be potentially targeted for treating metabolic disorders.
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spelling pubmed-93605462022-08-10 The emerging roles of PHOSPHO1 and its regulated phospholipid homeostasis in metabolic disorders Liu, Yi Wu, Yingting Jiang, Mengxi Front Physiol Physiology Emerging evidence suggests that phosphoethanolamine/phosphocholine phosphatase 1 (PHOSPHO1), a specific phosphoethanolamine and phosphocholine phosphatase, is involved in energy metabolism. In this review, we describe the structure and regulation of PHOSPHO1, as well as current knowledge about the role of PHOSPHO1 and its related phospholipid metabolites in regulating energy metabolism. We also examine mechanistic evidence of PHOSPHO1- and phospholipid-mediated regulation of mitochondrial and lipid droplets functions in the context of metabolic homeostasis, which could be potentially targeted for treating metabolic disorders. Frontiers Media S.A. 2022-07-26 /pmc/articles/PMC9360546/ /pubmed/35957983 http://dx.doi.org/10.3389/fphys.2022.935195 Text en Copyright © 2022 Liu, Wu and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Liu, Yi
Wu, Yingting
Jiang, Mengxi
The emerging roles of PHOSPHO1 and its regulated phospholipid homeostasis in metabolic disorders
title The emerging roles of PHOSPHO1 and its regulated phospholipid homeostasis in metabolic disorders
title_full The emerging roles of PHOSPHO1 and its regulated phospholipid homeostasis in metabolic disorders
title_fullStr The emerging roles of PHOSPHO1 and its regulated phospholipid homeostasis in metabolic disorders
title_full_unstemmed The emerging roles of PHOSPHO1 and its regulated phospholipid homeostasis in metabolic disorders
title_short The emerging roles of PHOSPHO1 and its regulated phospholipid homeostasis in metabolic disorders
title_sort emerging roles of phospho1 and its regulated phospholipid homeostasis in metabolic disorders
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360546/
https://www.ncbi.nlm.nih.gov/pubmed/35957983
http://dx.doi.org/10.3389/fphys.2022.935195
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