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Effects of mild obesity on outcomes in Japanese patients with COVID-19: a nationwide consortium to investigate COVID-19 host genetics

BACKGROUND: Obesity is reported to be a risk factor for severe disease in patients with coronavirus disease 2019 (COVID-19). However, there are no specific reports on the risk of severe disease according to body mass index (BMI) in Japan. Thus, this study aimed to investigate the effect of obesity s...

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Autores principales: Lee, Ho, Chubachi, Shotaro, Namkoong, Ho, Tanaka, Hiromu, Otake, Shiro, Nakagawara, Kensuke, Morita, Atsuho, Fukushima, Takahiro, Watase, Mayuko, Kusumoto, Tatsuya, Masaki, Katsunori, Kamata, Hirofumi, Ishii, Makoto, Hasegawa, Naoki, Harada, Norihiro, Ueda, Tetsuya, Ueda, Soichiro, Ishiguro, Takashi, Arimura, Ken, Saito, Fukuki, Yoshiyama, Takashi, Nakano, Yasushi, Mutoh, Yoshikazu, Suzuki, Yusuke, Murakami, Koji, Okada, Yukinori, Koike, Ryuji, Kitagawa, Yuko, Kimura, Akinori, Imoto, Seiya, Miyano, Satoru, Ogawa, Seishi, Kanai, Takanori, Fukunaga, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360639/
https://www.ncbi.nlm.nih.gov/pubmed/35945221
http://dx.doi.org/10.1038/s41387-022-00217-z
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author Lee, Ho
Chubachi, Shotaro
Namkoong, Ho
Tanaka, Hiromu
Otake, Shiro
Nakagawara, Kensuke
Morita, Atsuho
Fukushima, Takahiro
Watase, Mayuko
Kusumoto, Tatsuya
Masaki, Katsunori
Kamata, Hirofumi
Ishii, Makoto
Hasegawa, Naoki
Harada, Norihiro
Ueda, Tetsuya
Ueda, Soichiro
Ishiguro, Takashi
Arimura, Ken
Saito, Fukuki
Yoshiyama, Takashi
Nakano, Yasushi
Mutoh, Yoshikazu
Suzuki, Yusuke
Murakami, Koji
Okada, Yukinori
Koike, Ryuji
Kitagawa, Yuko
Kimura, Akinori
Imoto, Seiya
Miyano, Satoru
Ogawa, Seishi
Kanai, Takanori
Fukunaga, Koichi
author_facet Lee, Ho
Chubachi, Shotaro
Namkoong, Ho
Tanaka, Hiromu
Otake, Shiro
Nakagawara, Kensuke
Morita, Atsuho
Fukushima, Takahiro
Watase, Mayuko
Kusumoto, Tatsuya
Masaki, Katsunori
Kamata, Hirofumi
Ishii, Makoto
Hasegawa, Naoki
Harada, Norihiro
Ueda, Tetsuya
Ueda, Soichiro
Ishiguro, Takashi
Arimura, Ken
Saito, Fukuki
Yoshiyama, Takashi
Nakano, Yasushi
Mutoh, Yoshikazu
Suzuki, Yusuke
Murakami, Koji
Okada, Yukinori
Koike, Ryuji
Kitagawa, Yuko
Kimura, Akinori
Imoto, Seiya
Miyano, Satoru
Ogawa, Seishi
Kanai, Takanori
Fukunaga, Koichi
author_sort Lee, Ho
collection PubMed
description BACKGROUND: Obesity is reported to be a risk factor for severe disease in patients with coronavirus disease 2019 (COVID-19). However, there are no specific reports on the risk of severe disease according to body mass index (BMI) in Japan. Thus, this study aimed to investigate the effect of obesity stratified by BMI on the severity of COVID-19 in the general Japanese population. METHODS: From February 2020 to May 2021, 1 837 patients aged ≥18 years were enrolled in the Japan COVID-19 Task Force. Patients with known BMI and disease severity were analyzed. Severity was defined as critical if the patient was treated in the intensive care unit, required invasive mechanical ventilation, or died. RESULTS: Class 1 obesity (25.0 ≤ BMI < 30.0 kg/m(2)), class 2 obesity (30.0 ≤ BMI < 35.0 kg/m(2)), and class 3 or 4 obesity (BMI ≥ 35 kg/m(2)) were present in 29%, 8%, and 3% of the cases, respectively. Multiple logistic regression analysis with known risk factors for critical illness indicated that class 2 obesity was an independent risk factor for oxygenation (adjusted odds ratio, 4.75) and critical cases (adjusted odds ratio, 1.81). Class 1 obesity and class 3 or 4 obesity were independent risk factors for oxygen administration (adjusted odds ratios 2.01 and 3.12, respectively), but not for critical cases. However, no differences in the mortality rates were observed between the BMI classes (P = 0.5104). CONCLUSION: Obesity is a risk factor for respiratory failure in Japanese patients with COVID-19, regardless of the degree of obesity. However, it may not cause severe COVID-19 in a dose–response relationship with BMI. COVID-19 patients with mild obesity may benefit from aggressive intensive care.
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spelling pubmed-93606392022-08-09 Effects of mild obesity on outcomes in Japanese patients with COVID-19: a nationwide consortium to investigate COVID-19 host genetics Lee, Ho Chubachi, Shotaro Namkoong, Ho Tanaka, Hiromu Otake, Shiro Nakagawara, Kensuke Morita, Atsuho Fukushima, Takahiro Watase, Mayuko Kusumoto, Tatsuya Masaki, Katsunori Kamata, Hirofumi Ishii, Makoto Hasegawa, Naoki Harada, Norihiro Ueda, Tetsuya Ueda, Soichiro Ishiguro, Takashi Arimura, Ken Saito, Fukuki Yoshiyama, Takashi Nakano, Yasushi Mutoh, Yoshikazu Suzuki, Yusuke Murakami, Koji Okada, Yukinori Koike, Ryuji Kitagawa, Yuko Kimura, Akinori Imoto, Seiya Miyano, Satoru Ogawa, Seishi Kanai, Takanori Fukunaga, Koichi Nutr Diabetes Article BACKGROUND: Obesity is reported to be a risk factor for severe disease in patients with coronavirus disease 2019 (COVID-19). However, there are no specific reports on the risk of severe disease according to body mass index (BMI) in Japan. Thus, this study aimed to investigate the effect of obesity stratified by BMI on the severity of COVID-19 in the general Japanese population. METHODS: From February 2020 to May 2021, 1 837 patients aged ≥18 years were enrolled in the Japan COVID-19 Task Force. Patients with known BMI and disease severity were analyzed. Severity was defined as critical if the patient was treated in the intensive care unit, required invasive mechanical ventilation, or died. RESULTS: Class 1 obesity (25.0 ≤ BMI < 30.0 kg/m(2)), class 2 obesity (30.0 ≤ BMI < 35.0 kg/m(2)), and class 3 or 4 obesity (BMI ≥ 35 kg/m(2)) were present in 29%, 8%, and 3% of the cases, respectively. Multiple logistic regression analysis with known risk factors for critical illness indicated that class 2 obesity was an independent risk factor for oxygenation (adjusted odds ratio, 4.75) and critical cases (adjusted odds ratio, 1.81). Class 1 obesity and class 3 or 4 obesity were independent risk factors for oxygen administration (adjusted odds ratios 2.01 and 3.12, respectively), but not for critical cases. However, no differences in the mortality rates were observed between the BMI classes (P = 0.5104). CONCLUSION: Obesity is a risk factor for respiratory failure in Japanese patients with COVID-19, regardless of the degree of obesity. However, it may not cause severe COVID-19 in a dose–response relationship with BMI. COVID-19 patients with mild obesity may benefit from aggressive intensive care. Nature Publishing Group UK 2022-08-09 /pmc/articles/PMC9360639/ /pubmed/35945221 http://dx.doi.org/10.1038/s41387-022-00217-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lee, Ho
Chubachi, Shotaro
Namkoong, Ho
Tanaka, Hiromu
Otake, Shiro
Nakagawara, Kensuke
Morita, Atsuho
Fukushima, Takahiro
Watase, Mayuko
Kusumoto, Tatsuya
Masaki, Katsunori
Kamata, Hirofumi
Ishii, Makoto
Hasegawa, Naoki
Harada, Norihiro
Ueda, Tetsuya
Ueda, Soichiro
Ishiguro, Takashi
Arimura, Ken
Saito, Fukuki
Yoshiyama, Takashi
Nakano, Yasushi
Mutoh, Yoshikazu
Suzuki, Yusuke
Murakami, Koji
Okada, Yukinori
Koike, Ryuji
Kitagawa, Yuko
Kimura, Akinori
Imoto, Seiya
Miyano, Satoru
Ogawa, Seishi
Kanai, Takanori
Fukunaga, Koichi
Effects of mild obesity on outcomes in Japanese patients with COVID-19: a nationwide consortium to investigate COVID-19 host genetics
title Effects of mild obesity on outcomes in Japanese patients with COVID-19: a nationwide consortium to investigate COVID-19 host genetics
title_full Effects of mild obesity on outcomes in Japanese patients with COVID-19: a nationwide consortium to investigate COVID-19 host genetics
title_fullStr Effects of mild obesity on outcomes in Japanese patients with COVID-19: a nationwide consortium to investigate COVID-19 host genetics
title_full_unstemmed Effects of mild obesity on outcomes in Japanese patients with COVID-19: a nationwide consortium to investigate COVID-19 host genetics
title_short Effects of mild obesity on outcomes in Japanese patients with COVID-19: a nationwide consortium to investigate COVID-19 host genetics
title_sort effects of mild obesity on outcomes in japanese patients with covid-19: a nationwide consortium to investigate covid-19 host genetics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360639/
https://www.ncbi.nlm.nih.gov/pubmed/35945221
http://dx.doi.org/10.1038/s41387-022-00217-z
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