Cargando…

Transcranial ultrasound diagnostic value of hemodynamic cerebral changes in preterm infants for early-onset sepsis

BACKGROUND: Due to the limitation of blood culture diagnosis, this study sought to evaluate the cerebral hemodynamic changes by Doppler ultrasound for timely and objective diagnosis techniques in preterm infants with early onset-neonatal sepsis. METHODS: In this retrospective study, 86 preterm infan...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Chunmei, Fang, Chengzhi, Shang, Yanyan, Yao, Baozhen, He, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360823/
https://www.ncbi.nlm.nih.gov/pubmed/35958011
http://dx.doi.org/10.21037/tp-22-269
_version_ 1784764410355515392
author Liu, Chunmei
Fang, Chengzhi
Shang, Yanyan
Yao, Baozhen
He, Qi
author_facet Liu, Chunmei
Fang, Chengzhi
Shang, Yanyan
Yao, Baozhen
He, Qi
author_sort Liu, Chunmei
collection PubMed
description BACKGROUND: Due to the limitation of blood culture diagnosis, this study sought to evaluate the cerebral hemodynamic changes by Doppler ultrasound for timely and objective diagnosis techniques in preterm infants with early onset-neonatal sepsis. METHODS: In this retrospective study, 86 preterm infants treated at the Department of Neonatology, Renmin Hospital of Wuhan University from January 1, 2019 to March 31, 2021, were divided into the following 2 groups: (I) the early onset neonatal sepsis (EONS) group (G1, n=41); (II) the normal control group (G2, n=45). The cerebral hemodynamic changes were examined by transcranial ultrasound. Stata15.0 and SPSS26.0 software were used for the data analysis. The pair-wise comparisons of the receiver operating characteristic (ROC) curves were on the MedCalc18.2.1 software. For all the statistical analyses, P value <0.05 was considered significant. RESULTS: Sex, birth weight, and gestational age did not differ significantly between the groups (P>0.05); the peak systolic velocity (PSV), mean velocity (MV), end diastolic velocity (EDV) (cm/s), resistivity index (RI), pulsatility index (PI) of the anterior cerebral artery (ACA), middle cerebral artery (MCA), and posterior cerebral artery (PCA) differed significantly between 2 groups (P<0.05). In relation to the diagnostic sensitivity, the area under the receiver operating characteristic (AUROC) analyses showed that compared to IL-6 (0.95, 1.00), EDV of the ACA, and PSV, EDV and MV of the MCA and PCA had a higher sensitivity than the others (AUROC: 1, all 95% CI: 1.00, 1.00). The diagnostic points of the EDV and MV of the ACA were 9.8 and 17.3 cm/s, respectively, the PSV, EDV, and MV of the MCA were 55.9, 10.9, and 20.4 cm/s, respectively, and the PSV, EDV, and MV of the PCA were 27.5, 7.5, and 9.8 cm/s, respectively. CONCLUSIONS: The study showed that PI increases and RI decreases, MV increases, and cerebral blood flow increases in EONS. Further, the EDV and MV of the ACA and the PSV, EDV, and MV of the MCA and PCA showed higher sensitivity than IL-6.
format Online
Article
Text
id pubmed-9360823
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher AME Publishing Company
record_format MEDLINE/PubMed
spelling pubmed-93608232022-08-10 Transcranial ultrasound diagnostic value of hemodynamic cerebral changes in preterm infants for early-onset sepsis Liu, Chunmei Fang, Chengzhi Shang, Yanyan Yao, Baozhen He, Qi Transl Pediatr Original Article BACKGROUND: Due to the limitation of blood culture diagnosis, this study sought to evaluate the cerebral hemodynamic changes by Doppler ultrasound for timely and objective diagnosis techniques in preterm infants with early onset-neonatal sepsis. METHODS: In this retrospective study, 86 preterm infants treated at the Department of Neonatology, Renmin Hospital of Wuhan University from January 1, 2019 to March 31, 2021, were divided into the following 2 groups: (I) the early onset neonatal sepsis (EONS) group (G1, n=41); (II) the normal control group (G2, n=45). The cerebral hemodynamic changes were examined by transcranial ultrasound. Stata15.0 and SPSS26.0 software were used for the data analysis. The pair-wise comparisons of the receiver operating characteristic (ROC) curves were on the MedCalc18.2.1 software. For all the statistical analyses, P value <0.05 was considered significant. RESULTS: Sex, birth weight, and gestational age did not differ significantly between the groups (P>0.05); the peak systolic velocity (PSV), mean velocity (MV), end diastolic velocity (EDV) (cm/s), resistivity index (RI), pulsatility index (PI) of the anterior cerebral artery (ACA), middle cerebral artery (MCA), and posterior cerebral artery (PCA) differed significantly between 2 groups (P<0.05). In relation to the diagnostic sensitivity, the area under the receiver operating characteristic (AUROC) analyses showed that compared to IL-6 (0.95, 1.00), EDV of the ACA, and PSV, EDV and MV of the MCA and PCA had a higher sensitivity than the others (AUROC: 1, all 95% CI: 1.00, 1.00). The diagnostic points of the EDV and MV of the ACA were 9.8 and 17.3 cm/s, respectively, the PSV, EDV, and MV of the MCA were 55.9, 10.9, and 20.4 cm/s, respectively, and the PSV, EDV, and MV of the PCA were 27.5, 7.5, and 9.8 cm/s, respectively. CONCLUSIONS: The study showed that PI increases and RI decreases, MV increases, and cerebral blood flow increases in EONS. Further, the EDV and MV of the ACA and the PSV, EDV, and MV of the MCA and PCA showed higher sensitivity than IL-6. AME Publishing Company 2022-07 /pmc/articles/PMC9360823/ /pubmed/35958011 http://dx.doi.org/10.21037/tp-22-269 Text en 2022 Translational Pediatrics. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Liu, Chunmei
Fang, Chengzhi
Shang, Yanyan
Yao, Baozhen
He, Qi
Transcranial ultrasound diagnostic value of hemodynamic cerebral changes in preterm infants for early-onset sepsis
title Transcranial ultrasound diagnostic value of hemodynamic cerebral changes in preterm infants for early-onset sepsis
title_full Transcranial ultrasound diagnostic value of hemodynamic cerebral changes in preterm infants for early-onset sepsis
title_fullStr Transcranial ultrasound diagnostic value of hemodynamic cerebral changes in preterm infants for early-onset sepsis
title_full_unstemmed Transcranial ultrasound diagnostic value of hemodynamic cerebral changes in preterm infants for early-onset sepsis
title_short Transcranial ultrasound diagnostic value of hemodynamic cerebral changes in preterm infants for early-onset sepsis
title_sort transcranial ultrasound diagnostic value of hemodynamic cerebral changes in preterm infants for early-onset sepsis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360823/
https://www.ncbi.nlm.nih.gov/pubmed/35958011
http://dx.doi.org/10.21037/tp-22-269
work_keys_str_mv AT liuchunmei transcranialultrasounddiagnosticvalueofhemodynamiccerebralchangesinpreterminfantsforearlyonsetsepsis
AT fangchengzhi transcranialultrasounddiagnosticvalueofhemodynamiccerebralchangesinpreterminfantsforearlyonsetsepsis
AT shangyanyan transcranialultrasounddiagnosticvalueofhemodynamiccerebralchangesinpreterminfantsforearlyonsetsepsis
AT yaobaozhen transcranialultrasounddiagnosticvalueofhemodynamiccerebralchangesinpreterminfantsforearlyonsetsepsis
AT heqi transcranialultrasounddiagnosticvalueofhemodynamiccerebralchangesinpreterminfantsforearlyonsetsepsis