Imaging Glioblastoma Metabolism by Using Hyperpolarized [1-(13)C]Pyruvate Demonstrates Heterogeneity in Lactate Labeling: A Proof of Principle Study

PURPOSE: To evaluate glioblastoma (GBM) metabolism by using hyperpolarized carbon 13 ((13)C) MRI to monitor the exchange of the hyperpolarized (13)C label between injected [1-(13)C]pyruvate and tumor lactate and bicarbonate. MATERIALS AND METHODS: In this prospective study, seven treatment-naive pat...

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Detalles Bibliográficos
Autores principales: Zaccagna, Fulvio, McLean, Mary A., Grist, James T., Kaggie, Joshua, Mair, Richard, Riemer, Frank, Woitek, Ramona, Gill, Andrew B., Deen, Surrin, Daniels, Charlie J., Ursprung, Stephan, Schulte, Rolf F., Allinson, Kieren, Chhabra, Anita, Laurent, Marie-Christine, Locke, Matthew, Frary, Amy, Hilborne, Sarah, Patterson, Ilse, Carmo, Bruno D., Slough, Rhys, Wilkinson, Ian, Basu, Bristi, Wason, James, Gillard, Jonathan H., Matys, Tomasz, Watts, Colin, Price, Stephen J., Santarius, Thomas, Graves, Martin J., Jefferies, Sarah, Brindle, Kevin M., Gallagher, Ferdia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Radiological Society of North America 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360994/
https://www.ncbi.nlm.nih.gov/pubmed/35838532
http://dx.doi.org/10.1148/rycan.210076

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